Mechanical properties of the mouse femur after treatment with diclofenac and running exercises

• Autorzy: Trzaskowska Aleksandra , Mielcarek Sławomir , Lehmann Tomasz , Pruszyńska-Oszmałek Ewa , Kołodziejski Paweł , Głowacki Maciej

Identyfikatory

DOI

10.37190/ABB-02061-2022-03

• Języki publikacji: EN

Abstrakty

EN

The flexible properties of the bone are essential for the movement and protection of vital organs. The ability of a bone to resist fractures under the influence of large muscles and physical activity depends on its established mechanical properties. This article discusses how exercise such as treadmill running and taking non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, affect the musculoskeletal system by modifying the elastic and thermal properties of the left femur of a mouse. Methods: The research was conducted using 9-week-old C57BL/6J female mice. In order to investigate the elastic and thermal properties of bones, dynamic mechanical analysis (DMA) and differential scanning calorimetry (DSC) were performed. Results: The study of elastic properties, followed by in-depth statistical analysis, shows that taking diclofenac slightly reduces the elastic parameters of the bones under study. These changes are more pronounced in DSC studies, the shift of the observed endothermic peaks is on the order of several degrees with a simultaneous increase in the enthalpy of this process. Conclusions: The opposite effect of the applied factors – diclofenac and running – on the elastic properties of the bones of the examined mice was found. The external factors – running and diclofenac – modify the basic parameters of the endothermic process associated with the release of water.

Słowa kluczowe

EN

mechanical properties; mouse femur; NSAID; treadmill running; dynamical mechanical analysis; differential scanning; calorimetry

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2022
• Tom: Vol. 24, no. 2
• Strony: 130--139
• Opis fizyczny: Bibliogr. 40 poz., rys., tab., wykr.

Twórcy

autor

Trzaskowska Aleksandra

• ISQI, Faculty of Physics, Adam Mickiewicz University, Poznań, Poland.

autor

Mielcarek Sławomir

• ISQI, Faculty of Physics, Adam Mickiewicz University, Poznań, Poland.

autor

Lehmann Tomasz

• Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań, Poland.

autor

Pruszyńska-Oszmałek Ewa

• Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Poznań, Poland.

autor

Kołodziejski Paweł

• Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Poznań, Poland.

autor

Głowacki Maciej

• Department of Pediatrics Orthopedics and Traumatology, Poznan University of Medical Sciences, Poznań, Poland.

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