Właściwości, występowanie i biodegradacja ibuprofenu w środowisku wodnym

Marchlewicz, A.; Guzik, U.; Wojcieszyńska, D.

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Tytuł artykułu

Właściwości, występowanie i biodegradacja ibuprofenu w środowisku wodnym

Autorzy

Marchlewicz A. , Guzik U. , Wojcieszyńska D.

Treść / Zawartość

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Warianty tytułu

Properties, occurrence and biodegradation of ibuprofen in aquatic environment

Języki publikacji

Abstrakty

Konsekwencją powszechnego stosowania niesteroidowych leków przeciwzapalnych, w tym ibuprofenu, jest ich obecność zarówno w ściekach, jak i w wodach powierzchniowych, do których odprowadzane są ścieki z oczyszczalni komunalnych, co może prowadzić do pojawiania się farmaceutyków również w wodzie wodociągowej. Ze względu na małą zawartość ibuprofenu w środowisku wodnym nie obserwuje się toksyczności ostrej, natomiast z uwagi na stały kontakt organizmów z tym lekiem istotne jest poznanie mechanizmów toksyczności chronicznej. Ponadto wiedza na temat migracji ibuprofenu w środowisku wodnym oraz przebiegu jego biodegradacji jest niepełna. Opisano jedynie kilka gatunków mikroorganizmów (głównie grzybów) zdolnych do metabolizowania tego leku. Dotychczasowy stan wiedzy wykazuje, że biotransformacja ibuprofenu zachodzi prawdopodobnie przez jego hydroksylację do 1,2-dihydroksyibuprofenu. Jedynym opisanym szczepem bakterii zdolnym do wykorzystywania ibuprofenu jako źródła węgla i energii jest Sphingomonas sp. Ibu-2. Pierwszym etapem rozkładu tego leku jest tioestryfikacja, a następnie dochodzi do usunięcia łańcucha propionowego z równoczesnym utlenieniem pierścienia do 4-izobutylokatecholu, który podlega ekstradiolowemu rozszczepieniu. Poznanie dróg metabolizowania niesteroidowych leków przeciwzapalnych pozwoli na skuteczniejsze oczyszczanie ścieków komunalnych z tego typu zanieczyszczeń, a przez to znaczącą poprawę jakości wód powierzchniowych.

Common use of non-steroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, leads to drug presence in sewage but also in surface waters, which they enter with municipal treatment plants effluent. As a result, the drugs may also be found in tap water. Due to low ibuprofen concentration in aquatic environment, acute toxicity is not observed. Yet, continuous exposure of aquatic organisms to the drug makes it important to study chronic toxicity mechanisms. Moreover, knowledge of ibuprofen migration and the time course of its biodegradation in the aquatic environment is incomplete. Only a few microorganism species (mainly fungi) able to metabolize ibuprofen have been described. The current research suggests that ibuprofen biotransformation proceeds by its hydroxylation to 1,2-dihydroxyibuprofen. Sphingomonas spp. Ibu-2 is the only described bacterial strain able to use ibuprofen as a sole carbon and energy source. Thioestrification is the first step in ibuprofen degradation. Then, propionic chain is removed with simultaneous oxidation of aromatic ring to 4-isobutylcatechol, which is then cleaved by extradiol enzymes. Knowledge of pathways of NSAID metabolism will allow for more effective removal of such pollutants from municipal wastewater, resulting in a significant improvement of surface water quality.

Słowa kluczowe

ibuprofen woda biodegradacja

ibuprofen water biodegradation

Wydawca

Polskie Zrzeszenie Inżynierów i Techników Sanitarnych, Oddział Dolnośląski

Czasopismo

Ochrona Środowiska

Rocznik

2015

Tom

Vol. 37, nr 1

Strony

65--70

Opis fizyczny

Bibliogr. 60 poz., rys., atb.

Twórcy

autor

Marchlewicz A.

amarchlewicz@us.edu.pl

Uniwersytet Śląski w Katowicach, Wydział Biologii i Ochrony Środowiska, ul. Jagiellońska 28, 40-032 Katowice

autor

Guzik U.

urszula.guzik@us.edu.pl

Uniwersytet Śląski w Katowicach, Wydział Biologii i Ochrony Środowiska, ul. Jagiellońska 28, 40-032 Katowice

autor

Wojcieszyńska D.

danuta.wojcieszynska@us.edu.pl

Uniwersytet Śląski w Katowicach, Wydział Biologii i Ochrony Środowiska, ul. Jagiellońska 28, 40-032 Katowice

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