Comparative study on cytotoxicity activity of N-α-acylarginine ethyl ester

• Autorzy: Mhatre J.D. , Singare P.U.
• Języki publikacji: EN

Abstrakty

EN

Amino-acid derived compounds, for example N-α-lauroylarginine ethyl ester (LAE), N-α-myristoylarginine ethyl ester (MAE) and a 1:1 mixture of N-α-myristoylarginine ethyl ester with monolaurin (MAE + MLN) are examined for their cytotoxicity towards L929-Mouse connective tissue to explore their use as microbicidal agent, in comparison to sodium dodecylsulfate (SDS) as an anionic control detergent. MTT (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Cytotoxicity assay method was used to determine IC50 value. Cytotoxicity of MAE is found to be more toxic as compared to LAE, having IC50 value 0.052 mg/ml against 0.68 mg/ml of LAE. But MAE when mixed with monolaurin (1:1), showed less toxicity with IC50 0.89 mg/ml. These results suggest that a combination of MAE and Monolaurin can be a potential candidate for studying its microbicidal properties.

Słowa kluczowe

EN

cytotoxicity; arginine; IC50; microbicidal; monolaurin

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2013
• Tom: Vol. 8, iss. 1
• Strony: 1--7
• Opis fizyczny: Bibliogr. 13 poz., tab., rys.

Twórcy

autor

Mhatre J.D.

• Department of Chemistry, Shri. Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan 333001, India

autor

Singare P.U.

• Department of Chemistry, Bhavan’s College, Munshi Nagar, Andheri (West), Mumbai 4000058, India

Bibliografia

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