UPLC-MS/MS analysis of SZJ-1207 in mouse plasma and brain and application in pharmacokinetic studies

• Autorzy: Qi Dake , Sun Yingying , Hu Bingying , An Hai , Lin Haiyang , Fang Jinjun , Wei Yang

Identyfikatory

DOI

10.1556/1326.2022.01102

• Języki publikacji: EN

Abstrakty

EN

SZJ-1207 is an antidepressant natural product with a steroidal structure extracted from Stephanotis mucronata. It is a novel antidepressant candidate molecule and all its pharmacokinetic properties have not been reported. In this pharmacokinetic study in mice following oral administration, an accurate and sensitive UPLC-MS/MS method was established and evaluated to measure SZJ-1207 concentrations in mouse plasma and brain samples. The results provide information regarding the pharmacokinetics of SZJ-1207 as a potential antidepressant.

Słowa kluczowe

EN

SZJ-1207; pharmacokinetics; mouse brain; plasma

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2024
• Tom: Vol. 36, no. 2
• Strony: 99--105
• Opis fizyczny: Bibliogr. 27 poz., rys., wykr.

Twórcy

autor

Qi Dake

• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Sun Yingying

• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Hu Bingying

• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

An Hai

• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Lin Haiyang

• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Fang Jinjun

• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

autor

Wei Yang

• Zhejiang Key Laboratory of Neuropsychiatric Drug Research, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou 310013, Zhejiang, China

• https://orcid.org/0000-0001-6350-831X

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