Synthesis of (Z)-N-aryl-C-(pyrid-3-yl)-nitrones

• Autorzy: Sadowski Mikołaj , Mudyna Agnieszka , Knap Klaudia , Demchuk Oleg M. , Łapczuk Agnieszka

Identyfikatory

DOI

10.58332/scirad2023v2i4a02

• Języki publikacji: EN

Abstrakty

EN

In this work, new nitrones, derived from nicotinaldehyde and N-aryl-N-hydroxylamines are described, and methods for their synthesis, and purification are presented. Spectral characterisation of said nitrones is also presented.

Słowa kluczowe

EN

nitrones; heteroorganic chemistry

PL

nitrony; chemia heteroorganiczna

• Wydawca: Radomskie Towarzystwo Naukowe
• Czasopismo: Scientiae Radices
• Rocznik: 2023
• Tom: Vol. 2, Iss. 4
• Strony: 319--324
• Opis fizyczny: Bibliogr. 15 poz., 1 il. kolor., wykr.

Twórcy

autor

Sadowski Mikołaj

• Faculty of Chemical Engineering and Technology, Cracow University of Technology, 31-155 Kraków, Poland

autor

Mudyna Agnieszka

• Faculty of Chemical Engineering and Technology, Cracow University of Technology, 31-155 Kraków, Poland

autor

Knap Klaudia

• Faculty of Chemical Engineering and Technology, Cracow University of Technology, 31-155 Kraków, Poland

autor

Demchuk Oleg M.

• Faculty of Medicine, The John Paul II Catholic University of Lublin, Konstantynow 1J, 20-708 Lublin, Poland

autor

Łapczuk Agnieszka

• Faculty of Chemical Engineering and Technology, Cracow University of Technology, 31-155 Kraków, Poland

Bibliografia

• [1] Fhaner, C.; Joshi, K.; Tan, Y.; Nitrone Inhibition of Oxidation of Unsaturated Fats. 2016, Patent WO2016154022A1.
• [2] Cinar, H.; Ritter, H.; Polynitrones and Use Thereof for Cross-Linking Unsaturated Polymers. 2014, Patent US8883931B2.
• [3] Dorschner, K.; Albright, J.; Phenyl Nitrone Derivatives Useful as Seed Protectants. 1974, Patent US3834073A.
• [4] Kopke, R.D.; Floyd, R.A.; Towner, R.; Methods for Treating Brain Injury. 2012, Patent WO2012106654A1.
• [5] Proctor, P.H.; RollingProctor, D.M.; Method for Treatment of Radiologically-Dense Breasts. 2018, US10028943B2.
• [6] Fryźlewicz, A.; Łapczuk-Krygier, A.; Kula, K.; Demchuk, O.M.; Dresler, E.; Jasiński, R.; Regio- and Stereoselective Synthesis of Nitrofunctionalized 1,2-Oxazolidine Analogs of Nicotine. Chem. Heterocycl. Comp. 2020, 56(1), 120-122. DOI: 10.1007/s10593-020-02631-6
• [7] Kras, J.; Woliński, P.; Nagatsky, R.; Demchuk, O.M.; Jasiński, R.; Full Regio- and Stereoselective Protocol for the Synthesis of New Nicotinoids via Cycloaddition Processes with the Participation of Trans-Substituted Nitroethenes: Comprehensive Experimental and MEDT Study. Molecules 2023, 28(8), 3535. DOI: 10.3390/molecules28083535
• [8] Li, Z.; Cheng, C.; Ming, X.; Cong, Y.; Li, Q.; Wei, Z.; Ma, X.; A Study on the Reaction Mechanisms and Process Safety of Pyrisoxazole Synthesis. Org. Process Res. Dev. 2021, 25(11), 2482-2489. DOI: 10.1021/acs.oprd.1c00254
• [9] Siadati, S.A.; Mirabi, A.; Diels-Alder versus 1,3-Dipolar Cycloaddition Pathways in the Reaction of C20 Fullerene and 2-Furan Nitrile Oxide. Prog. React. Kinet. Mech. 2015, 40(4), 383-390. DOI: 10.3184/146867815X14413752286065
• [10] Siadati, S.A.; Beyond the Alternatives That Switch the Mechanism of the 1,3-Dipolar Cycloadditions from Concerted to Stepwise or Vice Versa: A Literature Review. Prog. React. Kinet. Mech. 2016, 41(4), 331-344. DOI: 10.3184/146867816X14719552202168
• [11] Siadati, S.A.; Rezazadeh, S.; The Extraordinary Gravity of Three Atom 4π-Components and 1,3-Dienes to C20-nXn Fullerenes; a New Gate to the Future of Nano Technology. Sci. Radices 2022, 1(1), 46-68. DOI: 10.58332/v22i1a04
• [12] Dondoni, A.; Franco, S.; Junquera, F.; Merchán, F.L.; Merino, P.; Tejero, T.; Synthesis of N-Benzyl Nitrones. Synth. Commun. 1994, 24(18), 2537-2550. DOI: 10.1080/00397919408010565
• [13] Kula, K.; Dresler, E.; Demchuk, OM.; Jasiński, R. Nowe N-Tlenki Aldimin Jako Prekursory Związków Heterocyklicznych o Potencjalnej Aktywności Biologicznej. Przem. Chem. 2015, 94(8), 1385. DOI: 10.15199/62.2015.8.27
• [14] Murray, R.W.; Singh, M.; 1H and 13C NMR Spectra of (Z)‐C‐aryl N‐Tert‐butyl Nitrones. Magn. Reason. Chem. 1991, 29(9), 962-963. DOI: 10.1002/mrc.1260290917
• [15] Shindo, H.; Umezawa, B.; Infrared Absorption Spectra of Aldonitrones. I. Infrared Spectra of Benzaldehyde N-Methyl and N-Phenyl Nitrones. Chem. Pharm. Bull. 1962, 10(6), 492-503. DOI: 10.1248/cpb.10.492

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).