Transfer of TLC screening methods to quantitative HPTLC–densitometry methods for pharmaceutical products containing amlodipine besylate, cefpodoxime proxetil, cetirizine 2HCl, diclofenac sodium, efavirenz, mefenamic acid, and atovaquone + proguanil HCl

• Autorzy: Zeng B. , Gu Y. , Sherma J.

Identyfikatory

DOI

10.1556/1326.2018.00523

• Języki publikacji: EN

Abstrakty

EN

Transfer of seven thin-layer chromatography (TLC) Global Pharma Health Fund E.V. Minilab protocols for screening counterfeit pharmaceutical products in the field to quantitative high-performance TLC (HPTLC)–densitometry methods was performed using a model process published previously. The developed and validated methods for tablets containing amlodipine besylate, cefpodoxime proxetil, cetirizine 2HCl, diclofenac sodium, efavirenz, mefenamic acid, and atovaquone + proguanil HCl involved the use of only relatively inexpensive and nontoxic solvents, Merck KGaA Premium Purity HPTLC silica gel 60 F₂₅₄ plates, semi-automated sample and standard solution application with a CAMAG Linomat 4, and automated densitometry with a CAMAG Scanner 3 for detection, identification, and quantification. In addition, previously transferred HPTLC–densitometry methods for azithromycin and for cephalexin were used to analyze a new product of each drug to demonstrate the applicability of the methods.

Słowa kluczowe

EN

Amlodipine besylate; cefpodoxime proxetil; cetirizine HCl; diclofenac sodium; efavirenz; mefenamic acid; atovaquone + proguanil HCl; azithromycin; cephalexin; thin-layer chromatography; TLC; densitometry; counterfeit drug analysis

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2019
• Tom: Vol. 31, no. 4
• Strony: 246--249
• Opis fizyczny: Bibliogr. 12 poz., rys., tab.

Twórcy

autor

Zeng B.

• Department of Chemistry, Lafayette College, Easton, PA, USA

autor

Gu Y.

• Department of Chemistry, Lafayette College, Easton, PA, USA

autor

Sherma J.

• Department of Chemistry, Lafayette College, Easton, PA, USA

Bibliografia

• [1] O'Sullivan, C.; Sherma, J. Acta Chromatogr. 2012, 24, 241–252.
• [2] Lianza, K.; Sherma, J. J. Liq. Chromatogr. Relat. Technol. 2013, 36, 2446–2462.
• [3] Popovic, N.; Sherma, J. Acta Chromatogr. 2014, 26, 615–623.
• [4] Global Pharma Health Fund e.V., http://www.gphf.org (accessed July 1, 2018).
• [5] Zhang, D.; Armour, E.; Sherma, J. Acta Chromatogr. 2017, 29, 484–486.
• [6] Armour, E.; Sherma, J. J. Liq. Chromatogr. Relat. Technol. 2017, 40, 282–286.
• [7] Zhang, D.; Strock, J.; Sherma, J. J. Liq. Chromatogr. Relat. Technol. 2016, 39, 277–280.
• [8] Nguyen, K.; Zhang, D.; Sherma, J. Trends Chromatogr. 2017, 11, 12–17.
• [9] Sharma, S.; Singh, S.; Baghel, S. J. Environ. Res. Dev. 2006, 1, 46–48.
• [10] Makhija, S. N.; Vavia, P. R. J. Pharm. Biomed. Anal. 2001, 25, 663–667.
• [11] Ferenczi-Fodor, K.; Vegh, Z.; Nagy-Tuak, A.; Renger, B.; Zeller, M. J. AOAC Int. 2001, 84, 1265–1276.
• [12] Kaale, E.; Risha, P.; Reich, E.; Layloff, T. P. J. AOAC Int. 2010, 93, 1836–1843.

Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).