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Dichlorodiphenyldichloroethylene (DDE) residue limit exceeded in pig tissues after feed-borne exposure to maximum allowed concentration

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Języki publikacji
EN
Abstrakty
EN
Monitoring of undesirable substances by the European Union indicates a presence of natural and anthropogenic pollutants in animal feed that may be of concern for the producers, as well as the veterinary services. Although the literature concerning toxicity of DDT (an insecticide widely used in the past) is extensive, less attention has been focused on the biological properties of DDE and its interactions with other contaminants. This study reports on the concentration profile of p,p’-DDE and two other ogranochlorines (p,p’-DDT, p,p’-DDD) in different tissues of immature gilts after 14, 28, and 42 days of oral exposure to p,p’-DDE alone (0.5mg·kg-1feed·day-1) and in mixture with naturally occurring mycotoxin zearalenone, ZEN (0.5+0.1mg·kg-1feed·day-1). The treatment resulted in a time-dependent accumulation of p,p’-DDE in fat-rich tissues. Although the pesticide’s concentration found in the adipose tissue exceeded the FAO/WHO maximum residue limit (5mg·kg-1 of fat), human dietary risk is little, as it requires a substantial consumption of such contaminated pork fat. Importantly, the high concentration of p,p’-DDE found in the adrenal glands suggests a threat to the animals’ health. Finally, a difference in the accumulation of p,p’-DDE was observed between the groups treated with this compound alone or in mixture with ZEN. This is most likely related to growth performance of the animals, altered by the endocrine disrupting activity of both compounds. Further research should evaluate the effects of p,p-DDE at the observed concentrations on the pigs’ health status and enable the studies of possible interactions with other environmental pollutants.
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Strony
1--9
Opis fizyczny
Bibliogr. 27 poz., tab., wykr.
Twórcy
autor
  • Department of Environmental Biotechnology, Faculty of Environmental Sciences, University of Warmia and Mazury in Olsztyn, ul. Słoneczna 45G, 10-709 Olsztyn, Poland; Phone: +48 89 5234151; Fax: +48 89 5234131
autor
  • Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, ul. Oczapowskiego 13, 10-718 Olsztyn, Poland
autor
  • Department of Environmental Biotechnology, Faculty of Environmental Sciences, University of Warmia and Mazury in Olsztyn, ul. Słoneczna 45G, 10-709 Olsztyn, Poland
autor
  • Department of Environmental Biotechnology, Faculty of Environmental Sciences, University of Warmia and Mazury in Olsztyn, ul. Słoneczna 45G, 10-709 Olsztyn, Poland
  • Department of Pharmacology and Toxicology, National Veterinary Research Institute, ul. Partyzantów 57, 24-100 Puławy, Poland
autor
  • Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, ul. Oczapowskiego 13, 10-718 Olsztyn, Poland
autor
  • Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, ul. Oczapowskiego 13, 10-718 Olsztyn, Poland
  • Institute of Animal Reproduction and Food Research of Polish Academy of Science, ul. Tuwima 10, 10-748 Olsztyn, Poland
autor
  • Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, ul. Oczapowskiego 13, 10-718 Olsztyn, Poland
Bibliografia
  • Adamsson, A., V. Salonen, J. Paranko, J. Toppari. 2009. Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p′-DDE) on steroidogenesis in the fetal rat testis and adrenal gland. Reproductive Toxicology 28: 66-74.
  • Arrebola, J.P., E. Mutch, M. Rivero, A. Choque, S. Silvestre, N. Olea, R. Ocaña-Riola, L.A. Mercado. 2012. Contribution of sociodemographic characteristics, occupation, diet and lifestyle to DDT and DDE concentrations in serum and adipose tissue from a Bolivian cohort. Environment International 38: 54–61.
  • ATSDR (Agency for Toxic Substances and Disease Registry; U.S. Department of Health And Human Services, Public Health Service). 2002. Toxicological profile for DDT, DDE, and DDD. http://www.atsdr.cdc.gov/toxprofiles. Accessed February 3, 2014.
  • Bergenstal, D., R. Hertz, M. Lipsett, R. Moy. 1960. Chemotherapy of adrenocortical cancer with o,p'-DDD. Annals of Internal Medicine 53: 672.
  • Bettinetti, R., S. Quadroni, G. Crosa, D. Harper, J. Dickie, M. Kyalo, K. Mavuti, S. Galassi. 2011. A preliminary evaluation of the DDT contamination of sediments in Lakes Natron and Bogoria (Eastern Rift Valley, Africa). AMBIO 40: 341–350.
  • CSO (Central Statistical Office). 2011. Statistical Yearbook of Agriculture. Warsaw 2011. http://www.stat.gov.pl. Accessed February 5, 2014.
  • Covaci, A., A. Gheorghe, P. Schepen. 2004. Distribution of organochlorine pesticides, polychlorinated biphenyls and α-HCH enantiomers in pork tissues. Chemosphere 56: 757–776.
  • Dati, E., G.I. Baroncelli, S. Mora, G. Russo, F. Baldinotti, D. Parrini, P. Erba, P. Simi, S. Bertelloni. 2009. Body composition and metabolic profile in women with complete androgen insensitivity syndrome. Sexual Development 3: 188–193.
  • EC (European Commission) Recommendation. 2006. European Commission recommendation of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding. Official Journal of the European Union, L 229, pp. 7–9 (23.08.2006).
  • FAO/WHO (Food and Agriculture Organization/World Health Organization). 2001. Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group. Pesticide residues in food 2000. Joint FAO/WHO Meeting on Pesticide Residue. FAO Plant Production and Protection Paper, 163.
  • Glynn, A., M. Aune, I. Nilsson, P.O. Darnerud, E.H. Ankarberg, A. Bignert, I. Nordlander. 2009. Declining levels of PCB, HCB and p,p'-DDE in adipose tissue from food producing bovines and swine in Sweden 1991-2004. Chemosphere 74: 1457-1462.
  • Gore, A.C. 2010. Neuroendocrine targets of endocrine disruptors. Hormones 9: 16-27.
  • Gould, D.C., R.S. Kirby, P. Amoroso. 2007. Hypoandrogen-metabolic syndrome: a potentially common and underdiagnosed condition in men. International Journal of Clinical Practice 61: 341–344.
  • Herendeen, R.A., W.R. Hill. 2004. Growth dilution in multilevel food chains. Ecological Modelling 178: 349–356.
  • Jakimiuk, E., M. Gajęcka, B. Jana, P. Brzuzan, Ł. Zielonka, E. Skorska-Wyszyńska, M. Gajęcki. 2009. Factors determining sensitivity of prepubertal gilts to hormonal influence of zearalenone. Polish Journal of Veterinary Sciences 12: 149-158.
  • Keifer, M.C., J. Firestone. 2007. Neurotoxicity of pesticides. Journal of Agromedicine 12: 17-25.
  • Kelce, W.R., C.R. Stone, S.C. Laws, L.E. Gray, J.A. Kemppainen, E.M. Wilson. 1995. Persistent DDT metabolite p,p’-DDE is a potent androgen receptor antagonist. Nature 375: 581-585.
  • Kitamura, S., Y. Shimizu, Y. Shiraga, M. Yoshida, K. Sugihara, S. Ohta. 2002. Reductive metabolism of p,p'-DDT and o,p'-DDT by rat liver cytochrome P450. Drug Metabolism and Disposition 30: 113–118.
  • Lund, B.O., Å. Bergman, I. Brandt. 1988. Metabolic activation and toxicity of a DDT-metabolite, 3-methylsulphonyl-DDE, in the adrenal zona fasciculata in mice. Chemico-Biological Interactions 65: 25–40.
  • Mayes, J.S., G.H. Watson. 2004. Direct effects of sex steroid hormones on adipose tissues and obesity. Obesity Reviews 5: 197-216.
  • Mayne, G.J., P.A. Martin, C.A. Bishop, H.J. Boermans. 2004. Stress and immune responses of nestling tree swallows (Tachycineta bicolor) and eastern bluebirds (Sialia sialis) exposed to nonpersistent pesticides and p,p'-dichlorodiphenyldichloroethylene in apple orchards of southern Ontario, Canada. Environmental Toxicology and Chemistry 23: 2930–2940.
  • Nag, S.K., M.K. Raikwar. 2011. Persistent organochlorine pesticide residues in animal feed. Environmental Monitoring and Assessment 174: 327–335.
  • NTP (National Toxicology Program; U.S. Department of Health and Human Services, Public Health Service). 2011. Dichlorodiphenyltrichloroethane. Report on Carcinogens, Twelfth Edition, pp. 143-145.
  • PMARD (Polish Ministry of Agriculture and Rural Development. 2012. Minister of Agriculture and Rural Development regulation of 6 February 2012 on the content of undesirable substances in animal feed. Dziennik Ustaw, pozycja 203 (published 22.02.2012, in Polish).
  • Rogan, W.J., A. Chen. 2005. Health risks and benefits of bis(4-chlophenyl)-1,1,1-trichloroethane (DDT). Lancet 366: 763–773.
  • Turusov, V., V. Rakitsky, L. Tomatis. 2002. Dichlorodiphenyltrichloroethane (DDT): ubiquity, persistence and risks. Environmental Health Perspectives 110: 125-128.
  • Weiner, A., I. Paprocka, A. Goł´biowska, K. Kwiatek. 2012. Prospects of implementation of meat and bone meal into the animal nutrition. Życie Weterynaryjne 87: 1035-1037 (in Polish).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-f6b3e09b-24e3-4428-8400-8eb90323cb30
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