Porous poly(lactic acid) based fibres as drug carriers in active dressings

• Autorzy: Dzierzkowska Ewa , Ścisłowska-Czarnecka Anna , Matwally Sara , Romaniszyn Dorota , Chadzińska Magdalena , Stodolak-Zych Ewa

Identyfikatory

DOI

10.37190/ABB-01548-2020-03

• Języki publikacji: EN

Abstrakty

EN

Purpose: The polymeric porous surface of fibres (PLA) may influence the kinetics of release of biologically active compounds (gentamicin, G and ethacridine lactate, R) affecting development of a bacterial biofilm. Methods: The porous fibres with different morphology were manufactured by the electrospinning method from ternary systems composed of PLA and selected solvents. Fibres morphology was examined using a scanning electron microscopy (SEM), their structure was analyzed by FT-IR ATR spectroscopy and differential scanning calorimetry (DSC). Changes in the drug release profile were measured using ICP/UV-Vis methods and the resulting bactericidal or bacteriostatic properties were tested by two-layer disk diffusion test in relation to various drug incorporation methods. Results: The porous fibres can be applied to produce drug-bearing membranes. The spectroscopic studies confirmed incorporation of gentamicin into the fibres and the presence of ethacridine lactate on their surface. Bimodal fibres distribution (P3) promoted faster release of gentamicin and ethacridine lactate from P3G and P3R materials. The electrospinning process coupled with the vapor induced phase separation influenced the glass transition temperature of the porous polymer fibres. The pre/post-electrospinning modification influenced the glass transition, maximum temperature of cold crystallization and melting point of the porous membrane, compared to the neat polymer. The polylactide fibres with gentamicin showed strong bactericidal effect on Gram-positive bacteria, while fibres with ethacridine lactate were bacteriostatic. Conclusions: The obtained fibres with complex surface morphology can be used as a membrane in active dressings as they make it possible to control the release profile of the active compounds.

Słowa kluczowe

EN

wound dressing; active dressing; nanostructured fibres; electrospun polylactide; drug delivery

PL

opatrunek na ranę; aktywny opatrunek; włókna nanostrukturalne; elektroprzędzony polilaktyd; dostawa narkotyków

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2020
• Tom: Vol. 22, no. 2
• Strony: 185--197
• Opis fizyczny: Bibliogr. 30 poz., il., tab., wykr.

Twórcy

autor

Dzierzkowska Ewa

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Kraków, Poland

autor

Ścisłowska-Czarnecka Anna

• Academy of Physical Education, Department of Physiotherapy, Section of Cosmetology, Kraków, Poland

autor

Matwally Sara

• International Centre of Electron Microscopy for Material Science, AGH University of Science and Technology, Faculty of Metals Engineering and Industrial Computer Science, Kraków, Poland

autor

Romaniszyn Dorota

• Jagiellonian University Medical College, Department of Microbiology, Kraków, Poland

autor

Chadzińska Magdalena

• Jagiellonian University, Faculty of Biology, Institute of Zoology and Biomedical Research, Kraków, Poland

autor

Stodolak-Zych Ewa

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, ul. A. Mickiewicza 30, 30-059 Kraków, Poland

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