In Vitro Degradation Behaviours of PDO Monofilament and Its Intravascular Stents with Braided Structure

• Autorzy: Wang C. E. , Zhang P. H.

Identyfikatory

DOI

10.1515/aut-2015-0031

• Języki publikacji: EN

Abstrakty

EN

Biodegradable intravascular stent has attracted more and more focus in recent years as an effective solution for angiostenosis. Ideal stents were expected to exhibit sufficient radial force to support the vascular wall, while suitable flexibility for the angioplasty. After vascular remodeling, stents should be degraded into small molecular and be eliminated from human body, causing no potential risk. In this paper, poly-p-dioxanone (PDO) monofilament was braided into net structure with four different braiding density, two of which exhibited sufficient radial force larger than 30 kPa, and three of which showed the bending rigidity within 11.7–88.1 N•mm2. The degradation behaviors of monofilaments and stents have been observed for 16 weeks. The findings obtained indicate that degradation first occurred in morphology region, which induced temporary increase of crystallinity, monofilament bending rigidity and stent mechanical properties. During this period, monofilament tends to be hard and brittle and lost its tensile properties. Then the crystalline region was degraded and stent mechanical properties decreased. All the results reveal that the PDO intravascular stents with braided structure were able to afford at least 10 weeks of sufficient support to the vascular wall.

Słowa kluczowe

EN

intravascular stent; braided structure; PDO; compression strength; bending rigidity

PL

stent wewnątrznaczyniowy; struktura pleciona; PDO; wytrzymałość na ściskanie; sztywność zginania

• Wydawca: Lodz University of Technology, Faculty of Material Technologies and Textile Design
• Czasopismo: Autex Research Journal
• Rocznik: 2016
• Tom: Vol. 16, no. 2
• Strony: 80--89
• Opis fizyczny: Bibliogr. 23 poz.

Twórcy

autor

Wang C. E.

• College of Textiles, Donghua University, Shanghai 201620, China
• Key Laboratory of Textile Science &Technology, Ministry of Education, China

autor

Zhang P. H.

• College of Textiles, Donghua University, Shanghai 201620, China
• Key Laboratory of Textile Science &Technology, Ministry of Education, China

Bibliografia

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Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę.