RP-HPTLC determination of the lipophilicity of some new derivatives of thiosemicarbazide and 1,2,4-triazole of sulphanylacetic acid

• Autorzy: Hawrył A. , Popiołek Ł , Dobosz M. , Pikuła E , Waksmundzka-Hajnos M.
• Języki publikacji: EN

Abstrakty

EN

Some new derivatives of thiosemicarbazide and the 1,2,4-triazole of sulphanylacetic acid have been chromatographed on RP-18 HPTLC plates with mobile phases containing water and an organic modifier (methanol, dioxane, acetone, 2-propanol, or tetrahydrofuran). Relationships between solute retention and modifier concentration were described by Snyder’s linear equation. The equation was used to determine R M 0 values, by extrapolation, and the S values denoting the slopes of the relationship between linear retention and mobile phase concentration; both values characterize the lipophilicity of the substances. Calculated values of R M 0 were correlated with log P values for the drugs investigated by use of the software HyperChem. Correlations between intercept ( R M 0 ) and slope ( S ) from the linear equations were also calculated. The effects of different mobile phase modifiers on experimentally obtained lipophilicity were also analysed and compared.

Słowa kluczowe

EN

thiosemicarbazides; 1,2,4-triazole of sulphanylacetic acid; potential drugs; lipophilicity; RP-TLC; R M 0

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2010
• Tom: Vol. 22, no. 1
• Strony: 37--55
• Opis fizyczny: Bibliogr. 22 poz., rys., tab.

Twórcy

autor

Hawrył A.

• Medical University of Lublin Department of Inorganic Chemistry Staszica 6 20-081 Lublin Poland

autor

Popiołek Ł

• Medical University of Lublin Department of Organic Chemistry Staszica 6 20-081 Lublin Poland

autor

Dobosz M.

• Medical University of Lublin Department of Organic Chemistry Staszica 6 20-081 Lublin Poland

autor

Pikuła E

• Medical University of Lublin Department of Inorganic Chemistry Staszica 6 20-081 Lublin Poland

autor

Waksmundzka-Hajnos M.

• Medical University of Lublin Department of Inorganic Chemistry Staszica 6 20-081 Lublin Poland

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