Virtual modelling of the impact of torsional loading on osteoporotic vertebrae buckling

• Autorzy: Chabarova Olga , Selivonec Jelena

Identyfikatory

DOI

10.37190/ABB-02392-2024-03

• Języki publikacji: EN

Abstrakty

EN

This study aimed to evaluate the biomechanical response or load transfer on the osteoporotic L1 vertebra under torsional loading. Methods: To achieve this goal, a numerical model of osteoporotic vertebra in various trabecular bone degenerations was developed and tested. The mechanical behavior of the model was represented taking into account the anisotropic properties of the cancellous bone, which provided a more realistic mechanical picture of the biological subsystem. To ensure the reliability of osteoporotic degradation, the thinning of cortical bone and the appearance of gaps between trabecular bone and cortical bone were also taken into account when creating the models. Results: Finite element (FE) analysis showed that the deformations of cortical bone thinning and detachment of the cortical bone from the trabecular tissue lead to local instability of the vertebra. As a result, the cortical bone of a vertebra loses its load-bearing capacity, even if the strength limit is not reached. Conclusions: The results obtained allow us to state that taking into account the thinning of the trabeculae, which creates voids, is extremely important for load-bearing capacity of osteoporotic vertebrae. However, a limitation of this study is the lack of experimental data to ensure consistency with the computer simulation results.

Słowa kluczowe

EN

osteoporosis; lumbar spine; vertebra; FEM; instability

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2024
• Tom: Vol. 26, no. 1
• Strony: 13--22
• Opis fizyczny: Bibliogr. 43 poz., rys., tab., wykr.

Twórcy

autor

Chabarova Olga

• Department of Applied Mechanics, Vilnius Gediminas Technical University, Vilnius, Lithuania.

autor

Selivonec Jelena

• Department of Applied Mechanics, Vilnius Gediminas Technical University, Vilnius, Lithuania.

Bibliografia

• [1] AYTURK U., PUTTLITZ C., Parametric convergence sensitivity and validation of a finite element model of the human lumbar spine, Comput. Methods Biomech. Biomed. Eng., 2011, 14, 695–705.
• [2] BLANCHARD R., MORIN C., MALANDRINO A. et al., Patient-specific fracture risk assessment of vertebrae: A multiscale approach coupling X-ray physics and continuum micromechanics, Int. J. Numer. Method. Biomed. Eng., 2016, 32, 1–36.
• [3] CHABAROVA O., ALEKNA V., KAČIANAUSKAS R., ARDATOV O., Finite element investigation osteoporotic lumbar L1 vertebra buckling in a presence of torsional load, Mechanics, 2017, 23, 326–333.
• [4] CHABAROVA O., KAČIANAUSKAS R., ALEKNA V., Buckling of osteoporotic lumbar: finite element analysis: research article, Research in Medical and Engineering Sciences, 2019, 8 (2), DOI: 10.31031/RMES.2019.08.000683.
• [5] CHABAROVA O., Numerical investgation of the effect of bone tissue pathology on human spine stability, Dissertation, Vilnius Gediminas Technical University, 2020.
• [6] CHOTAI S., GUPTA R., PENNINGS J.S. et al., Frailty and Sarcopenia: Impact on Outcomes Following Elective Degenerative Lumbar Spine Surgery, Spine (Phila, Pa 1976), 2022, 47, 1410–1417, DOI: https://doi.org/10.1097/BRS.0000000000004384.
• [7] DIAMOND T.H., CLARK W.A., KUMAR S.V., Histomorphometric analysis of fracture healing cascade in acute osteoporotic vertebral body fractures, Bone, 2007, 40, 775–780.
• [8] DU H.G., LIAO S.H., JIANG Z. et al., Biomechanical analysis of press-extension technique on degenerative lumbar with disc herniation and staggered facet joint, Saudi Pharm. J., 2016, 24, 305–311.
• [9] FINLEY S.M., BRODKE D.S., SPINA N.T. et al., FEBio finite element models of the human lumbar spine, Comput. Methods Biomech. Biomed. Engin., 2018, 21, 444–452, DOI: https://doi.org/10.1080/10255842.2018.1478967.
• [10] GARGES K.J., NOURBAKHSH A., MORRIS R. et al., A Comparison of the Torsional Stiffness of the Lumbar Spine in Flexion and Extension, J. Manipulative. Physiol. Ther., 2008, 31, 563–569.
• [11] GHADIRI M., Fracture Mechanics Analysis of Fourth Lumbar Vertebra in Method of Finite Element Analysis, Int. J. Adv. Biol. Biom. Res., 2014, 2, 2217–2224.
• [12] HAMILTON E.J., GHASEM-ZADEH A., GIANATTI E. et al., Structural Decay of Bone Microarchitecture in Men with Prostate Cancer Treated with Androgen Deprivation Therapy, J. Clin. Endocrinol. Metab., 2010, 95, E456–E463.
• [13] HUANG K., ZHANG J., Three-dimensional lumbar spine generation using variational autoencoder, Med. Eng. Phys., 2023, 120, 104046, DOI: https://doi.org/10.1016/J.MEDENGPHY.2023.104046.
• [14] JIANG Y., LIN D., GUO X. et al., Vertebral fractures are likely to occur in lumbar vertebra in patients with osteoporosis and even in osteopenia, Jt. Bone Spine., 2018, 77, 1627–1627, DOI: https://doi.org/10.1136/annrheumdis-2018-eular.5051.
• [15] JOHANSEN J.G., NORK M., GRAND F., Torsional instability of the lumbar spine, Riv. Neuroradiol., 1999, 12, 193–195.
• [16] JONES A.C., WILCOX R.K., Finite element analysis of the spine: Towards a framework of verification, validation and sensitivity analysis, Med. Eng. Phys., 2008, 30, 1287–1304.
• [17] KIM Y.H., WU M., KIM K., Stress Analysis of Osteoporotic Lumbar Vertebra Using Finite Element Model with Microscaled Beam-Shell Trabecular-Cortical Structure, J. Appl. Math., 2013, 1–6.22 O. CHABAROVA, J. SELIVONEC
• [18] KINZL M., SCHWIEDRZIK J., ZYSSET P.K., PAHR D.H., An experimentally validated finite element method for augmented vertebral bodies, Clin. Biomech., 2013, 28, 15–22.
• [19] LAN C., KUO C., CHEN C., HU H., Finite element analysis of biomechanical behavior of whole thoraco-lumbar spine with ligamentous effect, CJM, 2013, 26–41.
• [20] LOCHMÜLLER E.M., ECKSTEIN F., KAISER D., ZELLER J.B., LANDGRAF J., PUTZ R., STELDINGER R., Prediction of vertebral failure loads from spinal and femoral dual-energy X-ray absorptiometry, and calcaneal ultrasound: an in situ analysis with intact soft tissues, Bone, 1998, 23, 417–424.
• [21] LOUGHENBURY P.R., TSIRIKOS A.I., GUMMERSON N.W., Spinal biomechanics – biomechanical considerations of spinal stability in the context of spinal injury, Orthop. Trauma, 2016, 30, 369–377.
• [22] MADENCI E., GUVEN I., Fundamentals of Discretization, [in:] The Finite Element Method and Applications in Engineering Using ANSYS, Springer US, 2015, 35–74.
• [23] MAKNICKAS A., ALEKNA V., ARDATOV O. et al., FEM-based compression fracture risk assessment in osteoporotic lumbar vertebra L1, Appl. Sci.-Basel, 2019, 9, DOI: https://doi.org/10.3390/APP9153013.
• [24] MAZLAN M.H., TODO M., TAKANO H., YONEZAWA I., FiniteElement Analysis of Osteoporotic Vertebrae with First Lumbar (L1) Vertebral Compression Fracture, IJAPM, 2014, 4, 267–274.
• [25] MCDONALD K., LITTLE J., PEARCY M., ADAM C., Development of a Multi-Scale Finite Element Model of the Osteoporotic Lumbar Vertebral Body for the Investigation of Apparent Level Vertebra Mechanics and Micro-Level Trabecular Mechanics, K. Med. Eng. Phys., 2010, 32, 653–661.
• [26] MOLINARI L., FALCINELLI C., On the human vertebra computational modeling: a literature review, Meccanica, 2022, 57, DOI: https://doi.org/10.1007/s11012-021-01452-x.
• [27] MOLINARI L., FALCINELLI C., GIZZI A., DI MARTINO A., Effect of pedicle screw angles on the fracture risk of the human vertebra: A patient-specific computational model, J. Mech. Behav. Biomed. Mater., 2021, 116, 104359, DOI: https://doi.org/10.1016/J.JMBBM.2021.104359.
• [28] MONTEIRO N.M.B., DA SILVA M.P.T., FOLGADO J.O.M.G., MELANCIA J.P.L., Structural analysis of the intervertebral discs adjacent to an interbody fusion using multibody dynamics and finite element cosimulation, Multibody Syst. Dyn., 2011, 25, 245–270.
• [29] OKAMOTO Y., MURAKAMI H., DEMURA S. et al, The effect of kyphotic deformity because of vertebral fracture: a finite element analysis of a 10° and 20° wedge-shaped vertebral fracture model, The Spine Journal, 2015, 15, 713–720.
• [30] POLIKEIT A., NOLTE L.P., FERGUSON S.J., Simulated influence of osteoporosis and disc degeneration on the load transfer in a lumbar functional spinal unit, J. Biomech., 2004, 37, 1061–1069.
• [31] PIETRUSZCZAK S., INGLIS D., PANDE G.N., A fabric-dependent criterion for bone, J. Biomechanics, 1999, 32, 1071–1079.
• [32] PROVATIDIS C., VOSSOU C., KOUKOULIS I. et al., A pilot finite element study of an osteoporotic L1-vertebra compared to one with normal T-score, Comput. Methods. Biomech. Biomed. Engin., 2010, 13.185–195, DOI: https://doi.org/10.1080/10255840903099703.
• [33] SU X., SHEN H., SHI W. et al., Dynamic characteristics of osteoporotic lumbar spine under vertical vibration after cement augmentation, Am. J. Transl. Res., 2017, 9, 4036–4045.
• [34] TAYLOR D., Scaling effects in the fatigue strength of bones from different animals, J. Theor. Biology, 2000, 206, 299–306.
• [35] YANG L., DEMPSEY M., BRENNAN A. et al., Ireland DXA-FRAX may differ significantly and substantially to Web-FRAX, Arch. Osteoporos., 2023, 18, 43, DOI: https://doi.org/10.1007/S11657-023-01232-Y.
• [36] YANG S., XIA H., CONG M. et al., Unilateral pedicle screw fixation of lumber spine: A safe internal fixation method, Heliyon, 2022, 8, e11621, DOI: https://doi.org/10.1016/j.heliyon.2022.e11621.
• [37] ZAHAF S., HABIB H., MANSOURI B. et al., The Effect of the Eccentric Loading on the Components of the Spine, Global Journals Inc., 2016, 16, 2249–4596.
• [38] ZEBAZE R.M., GHASEM-ZADEH A., BOHTE A. et al., Intracortical remodelling and porosity in the distal radius and postmortem femurs of women: a cross-sectional study, The Lancet, 2010, 375, 1729–1736.
• [39] ZHU R., NIU W.X., ZENG Z.L. et al., The effects of muscle weakness on degenerative spondylolisthesis: A finite element study, Clin. Biomech., 2017, 41, 34–38.
• [40] 3D Slicer image computing platform, Available online: https://www.slicer.org/ [Accessed: 8 January 2023].
• [41] Ansys. Engineering Simulation Software, Available online: https://www.ansys.com/ [Accessed: 8 January 2023].
• [42] MeshLab, Available online: https://www.meshlab.net/ [Accessed: 8 January 2023].
• [43] Solidworks. 3D CAD Design Software and PDM Systems, Available online: https://www.solidworks.com/ [Accessed: 8 January 2023].