Computer modelling of pentoxifylline release from a cylinder-shaped hydroxylapatite carrier

• Autorzy: Mietła A. , Mycek B. , Wanat I. , Wąs J. , Zima A.
• Języki publikacji: EN

Abstrakty

EN

The main objective of this article is to present the basic stages of creating a computer simulation of medication release from an undegraded carrier. Additionally, an innovative approach was presented to the construction of a porous material used for making the carrier for the medication. The programme presented here is based on Cellular Automata, used as a tool for modelling physical, chemical and biological phenomena which change in time. The results of in-silico calculations have been compared with empirical results.

Słowa kluczowe

EN

modelling; cellular automata; porous material; solubility

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2012
• Tom: Vol. 8, no. 1
• Strony: 89--109
• Opis fizyczny: Bibliogr. 27 poz., rys., tab., wykr.

Twórcy

autor

Mietła A.

• AGH University of Science and Technology, Institute of Process Control, Mickiewicza 30 av, 30-059 Kraków

autor

Mycek B.

• Collegium Medicum UJ, Faculty of Pharmacy, Medyczna 9 av, 30 - 688 Kraków

autor

Wanat I.

• AGH University of Science and Technology, Institute of Process Control, Mickiewicza 30 av, 30-059 Kraków

autor

Wąs J.

• AGH University of Science and Technology, Institute of Automatics, Mickiewicza 30 av, 30-059 Kraków

autor

Zima A.

• AGH University of Science and Technology, Department of Biomaterials, Mickiewicza 30 av, 30-059 Kraków

Bibliografia

• [1] http://www.chemocare.com
• [2] http://www.doz.pl
• [3] http://leki-informacje.pl
• [4] http://www.infekcje.com.pl
• [5] http://mathworld.wolfram.com/LangtonsAnt.html
• [6] http://pl.wikipedia.org/wiki/Zbiór\_Mandelbrota
• [7] http://www.ceramika.agh.edu.pl/index.php?m=4\&p=10\&ktory\_art=12,
• [8] http://www.nauka.gov.pl/mn/gallery.jsp?place=Gallery\&gid=2438\&pid=10508,
• [9] Achasova, S., Bandman, O., Markova, V. and Piskunov, S. Parallel substitution algorithm. Theory and application. World Scientific, 1994.
• [10] Amigoni, F. and Schiaffonati, V. Model-baded Reasoning in Science, Technology and Medicine. Multiagent-Based Simulation in Biology a Critical Analysis. Springer, 2007.
• [11] Bandman, O. A lattice-gas model of fluid flow through tortuous channels of hydrophobic and hydrophilous porous materials. Russian Academy of Sciences, 2006.
• [12] Bandman, O. Experimental study of cellular-automata diffusion models. Russian Academy of Science, 2006.
• [13] Bandman, O. Parallel Composition of Asynchronous Cellular Automata Simulating Reaction Diffusion Processes. Cellular Automata for Research and Industry, 2010.
• [14] Barat, A.,Heather, J. and Ruskin, M. C.. Probabilistic methods for drug dissolution. part 2. Modeling a soluble binary drug delivery system dissolving in vitro. Elsevier Science B.V., 2006.
• [15] Bertrand, N., Gauthier, M. A., Bouvet, C., Moreau, P., Petitjean, A., Leroux, J. C. and Leblond J. New pharmaceutical applications for macromolecular binders J Control Release 155(2):200-210, 2011.
• [16] Bertrand, N., Leclair, G. and Hildgen, P. Modeling drug release from bioerodible microspheres using a Cellular Automaton. International Journal of Pharmaceutics, 2007.
• [17] Malarz, K. Cellular Automata, AGH-UST (in polish), 2011.
• [18] Sousa, A. O. ,Oliveira, D. and Moss, S. The penna model for biological ageing on a lattice: spatial consequences of child-care. Eur. Phys. J. B 9, 1999.
• [19] Mazo, R. M.. Brownian motion: fluctuations, dynamics and applications. Oxford University Press, 2002.
• [20] Grassi, M.,Grassi, G., Lapasin, R. and Colombo, I. Understanding Drug Release and Absorption Mechanisms: a physical and mathematical approach. CRC Press, 2006.
• [21] Lizbeth, M., Villalobosa, R., Sáncheza, M., Cruzb, J., Ganema, A. and Melgozab, L. Monte Carlo simulations for the study of drug release from cylindrical matrix systems with an inert nucleus. International Journal of Pharmaceutics, 2008.
• [22] Zima, A. Effect of modifiers on properties of multifunctional hydroxyapatite materials applied as the drug carriers.. PhD thesis, AGH-UST, Kraków, 2007.
• [23] Mycek, B. The studies of drugs kinetic release from hydroxyapatite implants. PhD thesis, 2005.
• [24] Freedman, D. Statistical models: theory and practice. Cambridge University Press, 2005.
• [25] Jaisingh, L. R. Statistics for the utterly confused. McGraw-Hill Professional, 2006.
• [26] Gajer, M.: Implementation of evolutionary algorithms in the discipline of Artificial Chemistry, Przeglad Elektrotechniczny (Electrical Review), ISSN 0033-2097, R. 87 NR 4/2011, pp. 198-202
• [27] Topa, P. Network Systems Modelled by Complex Cellular Automata Paradigm, Cellular Automata - Simplicity Behind Complexity, Alejandro Salcido (Ed.), ISBN: 978-953-307-230-2, InTech 2011.