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Computer modelling of pentoxifylline release from a cylinder-shaped hydroxylapatite carrier

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The main objective of this article is to present the basic stages of creating a computer simulation of medication release from an undegraded carrier. Additionally, an innovative approach was presented to the construction of a porous material used for making the carrier for the medication. The programme presented here is based on Cellular Automata, used as a tool for modelling physical, chemical and biological phenomena which change in time. The results of in-silico calculations have been compared with empirical results.
Słowa kluczowe
Rocznik
Strony
89--109
Opis fizyczny
Bibliogr. 27 poz., rys., tab., wykr.
Twórcy
autor
  • AGH University of Science and Technology, Institute of Process Control, Mickiewicza 30 av, 30-059 Kraków
autor
  • Collegium Medicum UJ, Faculty of Pharmacy, Medyczna 9 av, 30 - 688 Kraków
autor
  • AGH University of Science and Technology, Institute of Process Control, Mickiewicza 30 av, 30-059 Kraków
autor
  • AGH University of Science and Technology, Institute of Automatics, Mickiewicza 30 av, 30-059 Kraków
autor
  • AGH University of Science and Technology, Department of Biomaterials, Mickiewicza 30 av, 30-059 Kraków
Bibliografia
  • [1] http://www.chemocare.com
  • [2] http://www.doz.pl
  • [3] http://leki-informacje.pl
  • [4] http://www.infekcje.com.pl
  • [5] http://mathworld.wolfram.com/LangtonsAnt.html
  • [6] http://pl.wikipedia.org/wiki/Zbiór\_Mandelbrota
  • [7] http://www.ceramika.agh.edu.pl/index.php?m=4\&p=10\&ktory\_art=12,
  • [8] http://www.nauka.gov.pl/mn/gallery.jsp?place=Gallery\&gid=2438\&pid=10508,
  • [9] Achasova, S., Bandman, O., Markova, V. and Piskunov, S. Parallel substitution algorithm. Theory and application. World Scientific, 1994.
  • [10] Amigoni, F. and Schiaffonati, V. Model-baded Reasoning in Science, Technology and Medicine. Multiagent-Based Simulation in Biology a Critical Analysis. Springer, 2007.
  • [11] Bandman, O. A lattice-gas model of fluid flow through tortuous channels of hydrophobic and hydrophilous porous materials. Russian Academy of Sciences, 2006.
  • [12] Bandman, O. Experimental study of cellular-automata diffusion models. Russian Academy of Science, 2006.
  • [13] Bandman, O. Parallel Composition of Asynchronous Cellular Automata Simulating Reaction Diffusion Processes. Cellular Automata for Research and Industry, 2010.
  • [14] Barat, A.,Heather, J. and Ruskin, M. C.. Probabilistic methods for drug dissolution. part 2. Modeling a soluble binary drug delivery system dissolving in vitro. Elsevier Science B.V., 2006.
  • [15] Bertrand, N., Gauthier, M. A., Bouvet, C., Moreau, P., Petitjean, A., Leroux, J. C. and Leblond J. New pharmaceutical applications for macromolecular binders J Control Release 155(2):200-210, 2011.
  • [16] Bertrand, N., Leclair, G. and Hildgen, P. Modeling drug release from bioerodible microspheres using a Cellular Automaton. International Journal of Pharmaceutics, 2007.
  • [17] Malarz, K. Cellular Automata, AGH-UST (in polish), 2011.
  • [18] Sousa, A. O. ,Oliveira, D. and Moss, S. The penna model for biological ageing on a lattice: spatial consequences of child-care. Eur. Phys. J. B 9, 1999.
  • [19] Mazo, R. M.. Brownian motion: fluctuations, dynamics and applications. Oxford University Press, 2002.
  • [20] Grassi, M.,Grassi, G., Lapasin, R. and Colombo, I. Understanding Drug Release and Absorption Mechanisms: a physical and mathematical approach. CRC Press, 2006.
  • [21] Lizbeth, M., Villalobosa, R., Sáncheza, M., Cruzb, J., Ganema, A. and Melgozab, L. Monte Carlo simulations for the study of drug release from cylindrical matrix systems with an inert nucleus. International Journal of Pharmaceutics, 2008.
  • [22] Zima, A. Effect of modifiers on properties of multifunctional hydroxyapatite materials applied as the drug carriers.. PhD thesis, AGH-UST, Kraków, 2007.
  • [23] Mycek, B. The studies of drugs kinetic release from hydroxyapatite implants. PhD thesis, 2005.
  • [24] Freedman, D. Statistical models: theory and practice. Cambridge University Press, 2005.
  • [25] Jaisingh, L. R. Statistics for the utterly confused. McGraw-Hill Professional, 2006.
  • [26] Gajer, M.: Implementation of evolutionary algorithms in the discipline of Artificial Chemistry, Przeglad Elektrotechniczny (Electrical Review), ISSN 0033-2097, R. 87 NR 4/2011, pp. 198-202
  • [27] Topa, P. Network Systems Modelled by Complex Cellular Automata Paradigm, Cellular Automata - Simplicity Behind Complexity, Alejandro Salcido (Ed.), ISBN: 978-953-307-230-2, InTech 2011.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-f5442b0d-b6c4-41bd-bacd-c8af47e93b5e
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