Hematopoietic stem cell based therapy of immunosuppressive viral infection — Numerical simulations

• Autorzy: Korpusik A.

Identyfikatory

DOI

10.1016/j.bbe.2013.12.003

• Języki publikacji: EN

Abstrakty

EN

In the light of recent advantages in stem cell research and gene based therapies of viral infections, we present a numerical experiment referring to hematopoietic stem cell based therapy of immunosuppressive viral infection. We use a variation of basic mathematical model for impairment of help to simulate immune impairing infection. Next, we increase virus-specific CTL production (as in therapy) in different stages of infection. Obtained results are analyzed and compared with results from recent in vivo experiment.

Słowa kluczowe

EN

numerical modelling; virus; adaptive immune system; cellular immunity; immunosuppression; hematopoietic stem cells (HSC)

PL

modelowanie numeryczne; wirus; adaptacyjny układ odpornościowy; odporność komórkowa; komórka macierzysta

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2014
• Tom: Vol. 34, no. 2
• Strony: 125--131
• Opis fizyczny: Bibliogr. 18 poz., wykr.

Twórcy

autor

Korpusik A.

• Faculty of Technical Sciences, University of Warmia and Mazury, 10-719 Olsztyn, ul. Oczapowskiego 11, Poland

Bibliografia

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