Biomimetic fibrous composite membranes for bone tissue engineering

• Autorzy: Rajzer I. , Chrzanowski W. , Biniaś W. , Sarna E. , Janicki J.
• Języki publikacji: EN

Abstrakty

EN

One of the major challenges in biomaterials and tissue engineering is to guide the cell differentiation to the specific phenotype, therefore allow the formation of the tissue of certain type. This can be achieved by manipulating the structural, geometrical and chemical characteristics of the tissue engineering constructs. In our studies we concentrated on the chemical modifications of the polymer based materials for tissue engineering. The primary aim of our study was to incorporate nano size hydroxyapatite (n-HAp) crystals into the polymer fibres and form membranes, which are a core to the construction of novel scaffolds for tissue regeneration. We hypothesised that n-HAp will significantly improve the bioactivity of the polymer based membranes due to the presence of chemical cues. We developed a simple method to fabricate PLDL/n- HAp composite membranes using electrospinning process. The investigation showed that the incorporation of the n-HAp particles in the polymer spinning solution induced changes in the material surface morphology. FTIR analysis confirmed the presence of apatite on the surface of the membrane' fibers. The bioactivity analysis, which was based on SEM observation of the membranes surface, showed that after only 7 days immersion in SBF, the PLDL/n-HAp -membranes were completely covered by the apatite layer. This was not observed for pure PLDL membranes.

Słowa kluczowe

EN

tissue engineering; biomaterials; membranes

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2010
• Tom: Vol. 13, no. 93
• Strony: 2--5
• Opis fizyczny: Bibliogr. 16 poz., rys., wykr.

Twórcy

autor

Rajzer I.

• ATH, University of Bielsko-Biala, Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Materials, Department of Polymer Materials, Willowa 2, 43-309 Bielsko-Biała, Poland

autor

Chrzanowski W.

• University of Sydney, The Faculty of Pharmacy, Bank Building A15, Sydney, NSW 2006, AUS

autor

Biniaś W.

• ATH, University of Bielsko-Biala, Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Materials, Department of Polymer Materials, Willowa 2, 43-309 Bielsko-Biała, Poland

autor

Sarna E.

• ATH, University of Bielsko-Biala, Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Materials, Department of Polymer Materials, Willowa 2, 43-309 Bielsko-Biała, Poland

autor

Janicki J.

• ATH, University of Bielsko-Biala, Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Materials, Department of Polymer Materials, Willowa 2, 43-309 Bielsko-Biała, Poland

Bibliografia

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• [13] Hiep NT, Lee BT. Electro-spinning of PLGA/PCL blends for tissue engineering and their biocompatibility. Journal of Materials Science: Materials in Medicine, 2010 (in press).
• [14] Javiya S, Gupta YS, Singh K, Bhattacharya A. Porometry Studies of the Polysulfone Membranes on Addition of Poly(ethylene Glycol) in Gelation Bath During Preparation. Journal of the Mexican Chemical Society, 2008;52(2): 140-144.
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Uwagi

EN

This work was supported by the Polish Ministry of Science and Higher Education (project number: N N507550938).