Synthesis and Biological Screening of 3-Aryl-5-[(4′- difluoromethoxy)(3′-hydroxy)phenyl]-4,5-dihydro isoxazole

• Autorzy: Bhadani V. N. , Purohit H. D. , Purohit D. M.

Identyfikatory

DOI

10.18052/www.scipress.com/ILCPA.47.133

• Języki publikacji: EN

Abstrakty

EN

Isoxazoline derivatives shows various types of therapeutic activities like antimicrobial[1], antiinflammatory[ 2], anticonvulsant[3], Hypoglycemic[4] etc. getting to synthesized in view of 3-Aryl-5[(4′-difluoromethoxy)(3′-hydroxy)phenyl]-4,5-dihydro isoxazole (4a-4i) have been synthesized. All the newly synthesized compounds were screened for their antibacterial activity against S. aureus, M. luteus (Gram-positive bacteria), E. coli, S. thyphi (Gram-negative bacteria) and antifungal activity against Candida albicans (Fungi). The biological activities (MIC) of the synthesized compounds were compared with known standard drugs.

Słowa kluczowe

EN

isoxazole; antibacterial activity; antifungal activity

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2015
• Tom: Vol. 47
• Strony: 133--138
• Opis fizyczny: Bibliogr. 13 poz., wykr., wz.

Twórcy

autor

Bhadani V. N.

• Shree M. & N. Virani Science College, Department of Chemistry, Kalawad Road, Rajkot-360 005, Gujarat (India)

autor

Purohit H. D.

• Shree M. & N. Virani Science College, Department of Chemistry, Kalawad Road, Rajkot-360 005, Gujarat (India)

autor

Purohit D. M.

• Shree M. & N. Virani Science College, Department of Chemistry, Kalawad Road, Rajkot-360 005, Gujarat (India)

Bibliografia

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