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Cylindrospermopsin : cyanobacterial secondary metabolite. Biological aspects and potential risk for human health and life

Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Cylindrospermopsin (CYN) is a cytotoxin produced by several species of cyanobacteria, which occur all over the world. It was demonstrated that CYN has a wide spectrum of biological activity in animal cells, involving hepatotoxicity, genotoxicity, cytotoxicity and carcinogenic potential, and is considered as one of the factors that caused human poisoning in Palm Island (Australia) and in Caruaru (Brazil). This compound may be introduced into organism by several ways, including consumption of water, fishes and seafood as well as accidental swallowing or aerosol spray inhalation during recreational using of reservoirs covered by cyanobacterial blooms. The information about the CYN impact on environment and its degradation processes under natural conditions is scant. Taking this into consideration CYN should be regarded as a potential threat to human health and life. This review presents physicochemical characteristic and biological activity of CYN, occurrence in freshwaters and its sensitivity to the influence of some environmental factors.
Rocznik
Strony
442--449
Opis fizyczny
Bibliogr. 59 poz.,
Twórcy
autor
  • Department of Plant Physiology and Development, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland
autor
  • Department of Plant Physiology and Development, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland
autor
  • Department of Plant Physiology and Development, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland
autor
  • Department of Plant Physiology and Development, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland
autor
  • Department of Plant Physiology and Development, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland
Bibliografia
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  • 4. Banker R., Carmeli S., Hadas O., Teltsch B., Porat R. & Sukenik A. (1997). Identification of cylindrospermopsin in Aphanizomenon ovalisporum isolated from Lake Kinneret, Israel. J. Phycol. 33(4), 613–616. DOI: 10.1111/j.0022-3646.1997.00613.x.
  • 5. Banker R., Teltsch B., Sukenik A. & Carmeli S. (2000). 7-epicylindrospermopsin, a toxic minor metabolite of the cyanobacterium Aphanizomenon ovalisporum from Lake Kinneret. Israel. J. Nat. Prod. 63(3), 387–389. DOI: 10.1021/np990498m.
  • 6. Bazin E., Mourot A., Humpage A.R. & Fessard V. Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG. (2010). Environ. Mol. Mutagen. 51(3), 251–259. DOI: 10.1002/em.20539.
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  • 35. Mohamed Z. & Al-Shehri A. (2013). Assessment of cylindrospermopsin toxin in an arid Saudi lake containing dense cyanobacterial bloom. Environ. Monit. Assess. 185(3), 2157–2166.
  • 36. Neumann C., Bain P. & Shaw G. (2007). Studies on the comparative in vitro toxicology of the cyanobacterial metabolite deoxycylindrospermopsin. J. Toxicol. Environ. Health. 70(19), 1679–1686. DOI: 10.1080/15287390701434869.
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Bibliografia
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