Principles, Recent Developments and Perspectives in Boron Neutron Capture Therapy (BNCT)

• Autorzy: Sauerwein Wolfgang A.G. , Fischer Thomas , Sancey Lucie , Verry Camille , Matsuura Eiji , Moss Raymond L. , Wittig Andrea

Identyfikatory

DOI

10.5604/01.3001.0054.1824

• Języki publikacji: EN

Abstrakty

EN

For decades, BNCT was seen as an attractive concept and an intellectual challenge with no prospect of widespread clinical application. This situation has changed fundamentally in just a few years with the progress in accelerator technology. Low-energy, high- -intensity neutron sources can now be integrated into hospitals and are therefore directly available for patient treatment. A pioneer in this field is the development in Japan, where patients are already being treated in three hospitals, using in-house accelerator-based systems. Furthermore, the costs associated with the BNCT treatment of recurrent tumors in the head and neck area are already covered by the healthcare system. It is time to keep up to date with this technology and work to make it available to patients in high- -tech medicine in other countries, especially in Europe and North America. This short article summarizes the main principles of BNCT, outlines some aspects of its history and mentions ongoing projects as well as some hurdles that need to be overcome, as well as the scientific questions that need to be addressed for wider availability of the method.

Słowa kluczowe

EN

radiation oncology; fast neutron therapy; accelerator-based BNCT; ABNCT; high-linear-energy-transfer; LET; ICRU; IAEA; DGBNCT

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2023
• Tom: Vol. 19, no. 1
• Strony: 48--53
• Opis fizyczny: Bibliogr. 24 poz., tab.

Twórcy

autor

Sauerwein Wolfgang A.G.

• Deutsche Gesellschaft für Bor-Neutroneneinfangtherapie DGBNCT (Strahlenklinik, Universitätsklinikum Essen), Essen, Germany
• Neutron Therapy Research Center, Okayama University, Okayama, Japan
• Université Grenoble Alpes, Inserm UA7, Clinique Universitaire de Cancérologie - Radiothérapie, CHU Grenoble, France

• https://orcid.org/0000-0002-5027-5913

autor

Fischer Thomas

• Deutsche Gesellschaft für Bor-Neutroneneinfangtherapie DGBNCT (Strahlenklinik, Universitätsklinikum Essen), Essen, Germany
• Klinik und Poliklinik für Strahlentherapie und Radio-onokologie, Universitätsklinikum Würzburg, Julius-Maximilians-Universität, Würzburg, Germany

• https://orcid.org/0000-0003-4711-645X

autor

Sancey Lucie

• Deutsche Gesellschaft für Bor-Neutroneneinfangtherapie DGBNCT (Strahlenklinik, Universitätsklinikum Essen), Essen, Germany
• Université Grenoble Alpes, INSERM U1209 CNRS UMR 5309, Institute for Advanced Biosciences, Grenoble, France

• https://orcid.org/0000-0002-0084-3775

autor

Verry Camille

• Université Grenoble Alpes, Inserm UA7, Clinique Universitaire de Cancérologie - Radiothérapie, CHU Grenoble, France

• https://orcid.org/0000-0002-[phone]

autor

Matsuura Eiji

• Neutron Therapy Research Center, Okayama University, Okayama, Japan
• Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan

• https://orcid.org/0000-0003-1681-0684

autor

Moss Raymond L.

• BNCT Global GmbH, Essen, Germany

autor

Wittig Andrea

• Deutsche Gesellschaft für Bor-Neutroneneinfangtherapie DGBNCT (Strahlenklinik, Universitätsklinikum Essen), Essen, Germany
• Klinik und Poliklinik für Strahlentherapie und Radio-onokologie, Universitätsklinikum Würzburg, Julius-Maximilians-Universität, Würzburg, Germany

• https://orcid.org/0000-0002-1425-4090

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).