Application of alanine dosimetry in dose assessment for ocular melanoma patients undergoing proton radiotherapy : preliminary results

• Autorzy: Mierzwińska G. , Kłodowska M. , Michalec B. , Pędracka A. , Rydygier M. , Swakoń J. , Waligórski M. P. R.

Identyfikatory

DOI

10.1515/nuka-2015-0109

• Języki publikacji: EN

Abstrakty

EN

Basing on alanine solid state/electron paramagnetic resonance (EPR) dosimetry, a supplementary method of cumulatively recording the therapeutic dose received by ocular cancer patients undergoing fractionated proton radiotherapy is proposed. By applying alanine dosimetry during the delivery of consecutive fractions, the dose received within each fraction can be read out by EPR spectrometry and a fi nal permanent cumulative record of the total dose delivered obtained. The dose response of the alanine detector was found to be practically independent on its position within the extended proton Bragg peak region. Dose measurements based on entrance dose recorded in proton beams individually formed for each patient are presented. The described method will be applied as a complementary Quality Assurance procedure for patients undergoing proton radiotherapy at the Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland (IFJ PAN).

Słowa kluczowe

EN

alanine; EPR dosimetry; proton beam; proton radiotherapy; Quality Assurance (QA)

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2015
• Tom: Vol. 60, No. 3, part 2
• Strony: 609--613
• Opis fizyczny: Bibliogr. 10 poz., rys.

Twórcy

autor

Mierzwińska G.

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

autor

Kłodowska M.

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

autor

Michalec B.

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

autor

Pędracka A.

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

autor

Rydygier M.

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

autor

Swakoń J.

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

autor

Waligórski M. P. R.

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland
• Centre of Oncology, Maria Skłodowska-Curie Memorial Institute, Krakow Branch, 11 Garncarska Str., 31-115 Krakow, Poland

Bibliografia

• 1. ICRU. (2007). Prescribing, recording, and reporting proton-beam therapy. International Commission on Radiation Units and Measurements, Bethesda, Maryland. (ICRU Report 78).
• 2. Ahlers, F. J., & Schneider, C. C. J. (1991). Alanine ESR dosimetry: an assessment of peak-to-peak evaluation. Radiat. Prot. Dosim., 37, 117–122.
• 3. Schauer, D. A., Iwasaki, A., Romanyukha, A. A., Swartz, H. M., & Onori, S. (2006). Electron paramagnetic resonance (EPR) in medical dosimetry. Radiat. Meas., 41(Suppl.), S117–S123.
• 4. Michalec, B., Mierzwińska, G., Sowa, U., Ptaszkiewicz, M., Nowak, T., & Swakoń, J. (2012). Alanine dosimetry of 60 MeV proton beam – preliminary results. Nukleonika, 57, 503–506.
• 5. Mierzwinska, G., Michalec, B., Oglodek, I., Petelenz, B., & Waligorski, M. P. R. (2014). Alanine/EPR dosimetry as a potential tool for quality assurance in proton beam radiotherapy. Rom. Rep. Phys., 66, 54–60.
• 6. International Standard ISO/WD 15566.1. (1998). Practice for use of alanine-EPR dosimetry system (1998). International Organization of Standardization.
• 7. Michalec, B., Swakon, J., Sowa, U., Ptaszkiewicz, M., Cywicka-Jakiel, T., & Olko, P. (2010). Proton radiotherapy facility for ocular tumours at the IFJ PAN in Krakow, Poland. Appl. Radiat. Isot., 68, 738–742.
• 8. Absorbed dose determination in external beam radiotherapy. (2000). Vienna: International Atomic Energy Agency. (Technical Reports Series no. 398).
• 9. ICRU. (2006). Measurement quality assurance for ionizing radiation dosimetry. International Commission on Radiation Units and Measurements, Bethesda, Maryland. (ICRU Report 76).
• 10. Podgorsak, E. B. (Ed.). (2005). Radiation oncology physics: a handbook for teachers and students. Vienna: International Atomic Energy Agency.