Simultaneous qualitative and quantitative analysis for evaluating constituents of Atractylodis macrocephalae rhizome by UPLC-QTOF-MS

• Autorzy: Cao Di , Long Haishan , Shen Xuebin , Hu Bin , Xu Shixia , Zhang Huining , Zhao Zhongxiang , Han Jun

Identyfikatory

DOI

10.1556/1326.2023.01151

• Języki publikacji: EN

Abstrakty

EN

Atractylodis macrocephalae rhizome (AMR) belongs to medicine food homology. Its’ clinical application of invigorating the spleen-stomach of AMR was applied to various diseases. In this research, a UPLC-QTOF-MS method was developed for qualitative and quantitative analysis of AMR, simultaneously. A Waters Acquity BEH C18 column (2.1 mm 3 100 mm, 1.7 μm particle size) was used for separation of AMR multi-components. The column was eluted with a mobile phase of 0.1% formic acid-water and 0.1% formic acid-acetonitrile. Electron spray ionization with positive-ion mode and external standard method was utilized for quantifying the nine analytes in AMR. Constituents of AMR were scanned by UPLC-QTOF-MS and then identified by mass fragments and chromatographic information compared with the published literature and reference standards. Under positive mode, a total of 61 chemical compositions including 16 terpenoids, 8 polyacetylenes, 6 aromatics, 5 flavonoids, 5 coumarins, 5 organic acids, 4 amino acids, 3 fatty acids, 3 aliphatics, 2 steroids, and 2 alkenes, a nucleoside and an aldehyde were identified. Simultaneously, the contents of three amino acids (L-tyrosine, L-phenylalanine, and L-tryptophan), three sesquiterpenoids (atractylenolide Ⅲ, atractylenolide Ⅱ, and atractylenolide Ⅰ), a flavonoid (rutin), an organic acid (ferulic acid), and a pentacyclic triterpenoid (oleanolic acid) were determined in seventeen AMR batches. Amino acids and triterpenoid were quantified for the first time in AMR. The UPLC-QTOF-MS method developed in this article was reliable, practical, and useful for qualitative and quantitative evaluation of AMR multi-components.

Słowa kluczowe

EN

Atractylodis macrocephalae rhizome; qualitative analysis; quantitative analysis; UPLC-QTOF-MS

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2024
• Tom: Vol. 36, no. 4
• Strony: 333--343
• Opis fizyczny: Bibliogr. 54 poz., tab., wykr.

Twórcy

autor

Cao Di

• School of Pharmacy, Wannan Medical College, Wuhu, China

autor

Long Haishan

• School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China

autor

Shen Xuebin

• School of Pharmacy, Wannan Medical College, Wuhu, China

autor

Hu Bin

autor

Xu Shixia

• School of Pharmacy, Wannan Medical College, Wuhu, China

autor

Zhang Huining

• School of Pharmacy, Wannan Medical College, Wuhu, China

autor

Zhao Zhongxiang

• School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China

autor

Han Jun

• School of Pharmacy, Wannan Medical College, Wuhu, China
• Anhui Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Wuhu, China

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