Comparison of ESI and APCI sources in Q-TOF mass spectrometer in photodegradation study of selected psychotropic drugs

• Autorzy: Trawiński J. , Skibiński R. , Komsta Ł.

Identyfikatory

DOI

10.1556/1326.2017.29.2.2

• Języki publikacji: EN

Abstrakty

EN

Ultra high-performance liquid chromatography (UHPLC) coupled with high-resolution quadrupole time-of-flight (Q-TOF) mass spectrometry was used for the preliminary photodegradation study of nine new generation psychotropic drugs. Based on the above method, two ionization sample modes — electrospray and atmospheric pressure chemical ionization were used for the registration of photodegradation profiles of the selected drugs. Multivariate chemometric analysis showed that electrospray ionization (ESI) method is more specific than atmospheric pressure chemical ionization (APCI) in high-resolution mass spectrometry (HR-MS) analysis of the analyzed psychotropic drugs. It was noticed that, with the use of ESI method, more potential photodegradation products can be identified and lower limits of its detection can be obtained.

Słowa kluczowe

EN

PCA; ESI; APCI; Q-TOF; mass spectrometry

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2017
• Tom: Vol. 29, no. 2
• Strony: 161--172
• Opis fizyczny: Bibliogr. 26 poz., rys., tab.

Twórcy

autor

Trawiński J.

• Department of Medicinal Chemistry, Pharmaceutical Faculty, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland

autor

Skibiński R.

• Department of Medicinal Chemistry, Pharmaceutical Faculty, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland

autor

Komsta Ł.

• Department of Medicinal Chemistry, Pharmaceutical Faculty, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland

Bibliografia

• [1] R. Ekman, J. Sillbering, A.M. Westman-Brinkmalm, and A. Kraj, Mass Spectrometry Instrumentation, Interpretation, and Applications, John Wiley & Sons, 2009
• [2] M. Donegan and M. Browning, J. Liq. Chromatogr. Relat. Technol., 35, 2345 (2012)
• [3] S. Biselli, L. Hartig, H. Wegner, and Ch. Hummert, LCGC North Am., 23, 404 (2005)
• [4] T. Guo, Y. Shi, L. Zheng, F. Feng, F. Zheng, and W. Liu, J. Chromatogr. A, 1355, 73 (2014)
• [5] H. Keski-Hynnilä, M. Kurkela, E. Elovaara, L. Antonio, J. Magdalou, L. Luukkanen, J. Taskinen, and R. Kostiainen, Anal. Chem., 74, 3449 (2002)
• [6] T.R. Covey, B.A. Thomson, and B.B. Schneider, Mass Spectrom. Rev., 28, 870 (2009)
• [7] M. Herderich, E. Richling, R. Roscher, C. Schneider, W. Schwab, and H.U. Humpf, Chromatographia, 45, 127 (1997)
• [8] M. Holčapek, R. Jirásko, and M. Lísa, J. Chromatogr. A, 1217, 3908 (2010)
• [9] E.M. Thurman, I. Ferrer, and D. Barceló, Anal. Chem., 73, 5441 (2001)
• [10] N.C. Maragou, N.S. Thomaidis, and M.A. Koupparis, J. Am. Soc. Mass Spectrom., 22, 1826 (2011)
• [11] A. Wick, G. Fink, and T.A. Ternes, J. Chromatogr. A, 1217, 2088 (2010)
• [12] E.A. Straube, W. Dekant, and W. Völkel, J. Am. Soc. Mass Spectrom., 15, 1853 (2004)
• [13] T. Ghislain, P. Faure, and R. Michels, J. Am. Soc. Mass Spectrom., 23, 530 (2012)
• [14] A. Garcia-Ac, P.A. Segura, L. Viglino, Ch. Gagnon, and S. Sauvé, J. Mass Spectrom., 46, 383 (2011)
• [15] N. Llewellyn, P. Lloyd, M.D. Jürgens, and A.C. Johnson, J. Chromatogr. A, 1218, 8519 (2011)
• [16] M.S. Díaz-Cruz, M.J. López de Alda, R. López, and D. Barceló, J. Mass Spectrom., 38, 917 (2003)
• [17] S. Bailac, D. Barrón, V. Sanz-Nebot, and J. Barbosa, J. Sep. Sci., 29, 131 (2006)
• [18] S. Louw, M. Njoroge, N. Chigorimbo-Murfeu, and K. Chibale, Rapid Commun. Mass Spectrom., 26, 2431 (2012)
• [19] R. Verplaetse and J. Tytgat, J. Chromatogr. B, 878, 1987 (2010)
• [20] I.T. Wang, Y.T. Feng, and C.Y. Chen, J. Chromatogr. B, 878, 3095 (2010)
• [21] M.E. Rybak, D.L. Parker, and Ch.M. Pfeiffer, J. Chromatogr. B, 861, 145 (2008)
• [22] D.H. Kim and D.W. Lee, J. Chromatogr. A, 984, 153 (2003)
• [23] P. Keski-Rahkonnen, K. Huhtinen, R. Desai, D.T. Harwood, D.J. Handelsman, M. Poutanen, and S. Auriola, J. Mass Spectrom., 48, 1050 (2013)
• [24] J. Schuhmacher, D. Zimmer, F. Tesche, and V. Pickard, Rapid Commun. Mass Spectrom., 17, 1950 (2003)
• [25] S. Caetano, T. Decaestecker, R. Put, M. Daszykowski, J. Van Bocxlaer, and Y. Vander Heyden, Anal. Chim. Acta, 550, 92 (2005)
• [26] R. Skibiński and Ł. Komsta, Open Chem. 13, 763 (2015).

Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).