Determination of pancratistatin in mouse blood by ultra-liquid chromatography-tandem quadrupole mass spectrometry and its application

• Autorzy: Zhang Aiguo , Zhang Hanqi , Wang Xianqin , Chen Shuangqian , Jin Yongxi

Identyfikatory

DOI

10.1556/1326.2023.01114

• Języki publikacji: EN

Abstrakty

EN

In this study, a UPLC-MS/MS method was developed for determination of pancratistatin in the mouse blood, and the pharmacokinetics of pancratistatin in mice after intravenous (5 mg kg1) and intragastric (15mg kg1) administration was studied. HSS T3 column was used for separation with mobile phases of acetonitrile and 0.1% formic acid using gradient elution procedure. The blood sample was treated by protein precipitant with acetonitrile, midazolam was used as internal standard (IS). Multiple reaction monitoring mode (MRM) was used for quantitative analysis, m/z 326.2→83.8 for pancratistatin and m/z 326.2→291.4 for IS in electrospray (ESI) positive interface. It showed a good linear in the range of 10–4,000 ng mL1 (r > 0.998); the intra-day and inter-day precision was <15%, and the accuracy was 93%–105%. The recovery was better than 82%, and the matrix effect was 94%–105%. The developed UPLC-MS/MS method was fast, selective, and suitable for the pharmacokinetics of pancratistatin in mice

Słowa kluczowe

EN

pancratistatin; pharmacokinetics; UPLC-MS/MS; bioavailability

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2024
• Tom: Vol. 36, no. 2
• Strony: 143--149
• Opis fizyczny: Bibliogr. 22 poz., rys., wykr.

Twórcy

autor

Zhang Aiguo

• Department of Geriatrics, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medicine University, Wenzhou, China

autor

Zhang Hanqi

• Analytical and Testing Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Wang Xianqin

• Analytical and Testing Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Chen Shuangqian

• Department of Rehabilitation Therapy, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medicine University, Wenzhou, China

• https://orcid.org/0009-0003-3701-0800

autor

Jin Yongxi

• Department of Rehabilitation, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medicine University, Wenzhou, China

• https://orcid.org/0000-0002-0191-4168

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