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A novel method to design an electro-kinetic platform based on complementary metal-oxide semiconductor technology using SKILL scripting of cadence

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The dielectrophoresis (DEP) is the motion of polarizable particles which is a result of the interaction between a non-uniform electric field and the induced dipole moment of these particles. The electro-kinetic DEP is a widely used technique for biological cells' manipulation, characterization and separation. The electro-kinetic DEP consists of three major configurations, they are; traveling wave dielectrophoresis (twDEP), electro-rotation dielectrophoresis (rotDEP), and levitation (levDEP). In this paper, a design of electrokinetic platform that includes the three electrokinetic configurations is presented and discussed. The design of the electrokinetic platform is implemented and simulated using 130 nm complementary metal-oxide-semiconductor (CMOS) technology. Also, this paper presents a developed technique to design the electrokinetic platform's electrodes. This developed technique is the usage of SKILL scripting of cadence (SSC) language. CMOS is a technology which is used to fabricate integrated circuits (IC). SKILL is a scripting language which supports the automation of a specific layout design by commands. The layout of electrokinetic DEP platform is developed using SSC. The performance of the developed electrokinetic platform using SSC versus the platforms based on the other traditional techniques is presented and evaluated using COMSOL Multiphysics®.
Twórcy
  • Biomedical Engineering Department, Helwan University, Cairo, Egypt; Center of Nano Electronics and Devices (CND), Zewail City of Science and Technology and The American University in Cairo (AUC), Cairo, Egypt
  • Biomedical Engineering Department, Helwan University, Cairo, Egypt; Center of Nano Electronics and Devices (CND), Zewail City of Science and Technology and The American University in Cairo (AUC), Cairo, Egypt; Electronics and Communication Engineering Department (ECE), Kuwait College of Science and Technology, Kuwait
autor
  • Center of Nano Electronics and Devices (CND), Zewail City of Science and Technology and The American University in Cairo (AUC), Cairo, Egypt
Bibliografia
  • [1] Pohl HA, Pohl HA. Dielectrophoresis: the behavior of neutral matter in nonuniform electric fields. Cambridge: Cambridge University Press; 1978. p. 80.
  • [2] Eldeeb MA, Ghallab YH, Ismail Y, El Ghitani H. Fully integrated mixed mode interface circuit in 65 nm CMOS for leukemia detection and classification. IEEE International Symposium on Circuits and Systems (ISCAS), May. IEEE; 2018. p. 1–5.
  • [3] Hartley L, Kaler KV, Luo J, Paul R. Discrete planar electrode dielectrophoresis systems. Electrical and Computer Engineering. Engineering Innovation: Voyage of Discovery. IEEE 1997 Canadian Conference, vol. 1. 1997. pp. 185–92.
  • [4] Cetin B, Li D. Review dielectrophoresis in microfluidics technology. Electrophoresis 2011;32:2410–27.
  • [5] Cen EG, Dalton C, Li Y, Adamia S, Pilarski LM, Kaler KV. A combined dielectrophoresis, traveling wave dielectrophoresis and electrorotation microchip for the manipulation and characterization of human malignant cells. J Microbiol Methods 2004;58(3):387–401.
  • [6] Baker R, Jacob. CMOS: circuit design layout and simulation, vol. 1. John Wiley & Sons; 2008.
  • [7] Mudanyali O, Mcleod E, Luo W, Greenbaum A, Coskun AF, Hennequin Y, et al. Wide-field optical detection of nanoparticles using on-chip microscopy and self-assembled nanolenses. Nature Photon 2013;7:247–54.
  • [8] Lu S, Senevirathna B, Dandin M, Smela E, Abshire P. System integration of IC chips for lab-on-CMOS applications. IEEE International Symposium on Circuits and Systems (ISCAS), May. IEEE; 2018. p. 1–5.
  • [9] Temiz Y, Lovchik RD, Kaigala GV, Delamarche E. Lab-on-a- chip devices: how to close and plug the lab? Microelectron Eng 2015;132:156–75.
  • [10] Barnes, Timothy J. SKILL: a CAD system extension language. Proceedings of the 27th ACM/IEEE Design Automation Conference. ACM; 1991. p. 266–71.
  • [11] Spherotech - technical - characteristics of polystyrene particles. Retrieved from: http://www.spherotech.com/particle.html.
  • [12] Jones TB. Basic theory of dielectrophoresis and electrorotation. Eng Med Biol Magaz IEEE 2003;22(6):33–42.
  • [13] Abdelbaset R, Ghallab YH, Abdelhamid H, Ismail Y. A 2D model of different electrode shapes for traveling wave dielectrophoresis. 28th International Conference on Microelectronics (ICM), December. IEEE; 2016. p. 257–60.
  • [14] Abdelbaset R, Ghallab YH, Abdelhamid H, Ismail Y, El- Wakad MT. A 3D model of quadrupole dielectrophoresis levitation. IEEE 59th International Midwest Symposium on Circuits and Systems (MWSCAS), October. IEEE; 2016. p. 1–4.
  • [15] Ibrahim MF, Ghalab YH, Badawy W. Toward a 3D model of differential electric-field sensitive field effect transistor (DeFET). 1st Microsystems and Nanoelectronics Research Conference, 2008 (MNRC 2008), October. IEEE; 2008. p. 141–4.
Uwagi
PL
Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).
Typ dokumentu
Bibliografia
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bwmeta1.element.baztech-eae6d49b-5418-4eb1-a674-1c4a20bffe47
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