In vivo measurement of radiation dose during brachytherapy treatment using scintillation detectors

• Autorzy: Sobiech Bogna , Winiecki Janusz , Witkiewicz-Łukaszek Sandra , Zorenko Yuriy , Makarewicz Roman , Wróbel Patrycja

Identyfikatory

DOI

10.2478/pjmpe-2024-0036

• Języki publikacji: EN

Abstrakty

EN

Introduction: In vivo verification of the delivered dose in brachytherapy remains an unsolved dosimetric problem. Conventional detectors based on ionization chambers, semiconductors or thermoluminescent (TL) materials based on LiF or Al2O3:C compounds cannot be used for this purpose. The first way to solve this problem is to use dosimetric materials that can be placed in the patient’s body to record the delivered radiation dose in-situ using the OSL and/or scintillation phenomena. Material and Methods: In this work, it was proposed to use a known scintillation crystal of Ce<sup3+</sup> doped Ga₃Ga₃Al₂O₁₂:Ce garnet (GAGG:Ce) attached with a long optical fiber to measure in situ the radiation dose during brachytherapy treatment. The measurements were first performed in a phantom, and then on patients in the clinical conditions of the Oncology Center in Bydgoszcz. Results: The obtained results are very encouraging. Luminescence spectra from scintillators were recorded using a long optical fiber and a sensitive spectrometer, which can be placed in a safe place. Measurements on the phantom showed the perfect linear correlation between the dose and signal registered by the detector based on the GAGG:Ce crystal. Meanwhile, clinical measurements are subject to some uncertainty regarding the accuracy of detector placement in the treatment planning system and the possible passive emission response of the optical fiber. Conclusion: Scintillation crystals combined with optical fibers and very sensitive luminescence spectrometers create an ideal measurement system for in situ determining the dose of various ionizing radiations. However, their use in clinical practice requires the development of procedures for precisely positioning the detector in relation to the radiation target.

Słowa kluczowe

EN

brachytherapy; in vivo; scintillation

• Wydawca: Polskie Towarzystwo Fizyki Medycznej
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2024
• Tom: Vol. 30, Iss. 4
• Strony: 289--293
• Opis fizyczny: Bibliogr. 7 poz., rys., tab.

Twórcy

autor

Sobiech Bogna

• Medical Physics Department, Oncology Center in Bydgoszcz, Poland

autor

Winiecki Janusz

• Medical Physics Department, Oncology Center in Bydgoszcz, Poland
• Department of Oncology and Brachytherapy, Collegium Medicum in Bydgoszcz of Nicholas Copernicus University in Toruń, Poland

• https://orcid.org/0000-0001-9330-1547

autor

Witkiewicz-Łukaszek Sandra

• Department of Physics, Kazimierz Wielki University, Bydgoszcz, Poland

autor

Zorenko Yuriy

• Medical Physics Department, Oncology Center in Bydgoszcz, Poland
• Department of Physics, Kazimierz Wielki University, Bydgoszcz, Poland

• https://orcid.org/0000-0001-6641-3172

autor

Makarewicz Roman

• Department of Oncology and Brachytherapy, Collegium Medicum in Bydgoszcz of Nicholas Copernicus University in Toruń, Poland

autor

Wróbel Patrycja

• Medical Physics Department, Oncology Center in Bydgoszcz, Poland

Bibliografia

• 1. Andersen CE, Nielsen SK, Greilich S, Helt‐Hansen J, Lindegaard JC, Tanderup K. Characterization of a fiber‐coupled luminescence dosimetry system for online in vivo dose verification during brachytherapy. Medical Physics. 2009;36(3):708-718. https://doi.org/10.1118/1.3063006
• 2. Seitz B, Campos Rivera N, Stewart AG. Energy Resolution and Temperature Dependence of Ce:GAGG Coupled to Silicon Photomultipliers. IEEE Trans Nucl Sci. 2016;63(2):503-508. https://doi.org/10.1109/tns.2016.2535235
• 3. Sharma R, Jursinic PA. In vivo measurements for high dose rate brachytherapy with optically stimulated luminescent dosimeters. Medical Physics. 2013;40(7). https://doi.org/10.1118/1.4811143
• 4. Jaselskė E, Adlienė D, Rudžianskas V, Urbonavičius BG, Inčiūra A. In vivo dose verification method in catheter based high dose rate brachytherapy. Physica Medica. 2017;44:1-10. https://doi.org/10.1016/j.ejmp.2017.11.003
• 5. Tenhunen M, Lahtinen T, Forss M, Kulmala J, Pitkänen M, Pitkänen U. Accuracy of Dose Delivery in Gynecological Brachytherapy. Acta Oncologica. 1997;36(5):527-529. https://doi.org/10.3109/02841869709001309
• 6. Fonseca GP, Johansen JG, Smith RL, et al. In vivo dosimetry in brachytherapy: Requirements and future directions for research, development, and clinical practice. Physics and Imaging in Radiation Oncology. 2020;16:1-11. https://doi.org/10.1016/j.phro.2020.09.002
• 7. Suchowerska N, Jackson M, Lambert J, Yin YB, Hruby G, McKenzie DR. Clinical Trials of a Urethral Dose Measurement System in Brachytherapy Using Scintillation Detectors. International Journal of Radiation Oncology*Biology*Physics. 2011;79(2):609-615. https://doi.org/10.1016/j.ijrobp.2010.03.030

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025).