Development and validation of a dissolution method for novel fixed dose combination of etodolac and propranolol hydrochloride tablets by RP-HPLC

• Autorzy: Mohan A. , Dhayalamurthi S , Anandan P , Saravanan D
• Języki publikacji: EN

Abstrakty

EN

The present study reports the dissolution method for a novel fixed dose combination (FDC) containing etodolac (ET) and propranolol hydrochloride (PH) developed utilizing USP Apparatus 1 (basket) at 100 rpm with 1000 mL of phosphate buffer (pH 6.8; 0.05 M) medium at 37°C. An isocratic reversed-phase liquid chromatographic (RPLC) method was also developed for the simultaneous determination of ET and PH on an octadecylsilica column using phosphate buffer (pH 5.5) and acetonitrile (60:40, υ/υ) as the mobile phase with ultraviolet (UV) detection at 292 nm. Validation data were obtained, which demonstrated that the dissolution methodology is accurate, precise, linear, and rugged for the combination tablets.

Słowa kluczowe

EN

etodolac; propranolol hydrochloride; fixed dose combination; dissolution validation; isocratic reversed-phase liquid chromatography

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2011
• Tom: Vol. 23, no. 4
• Strony: 551--566
• Opis fizyczny: Bibliogr. 20 poz., rys., tab.

Twórcy

autor

Mohan A.

• National College Department of Chemistry Trichirapalli Pin code 620001 Tamilnadu India

autor

Dhayalamurthi S

• Mother Theresa Post Graduate & Research Institute of Health Sciences Department of Chemistry, College of Pharmacy Gorimedu Puducherry Pin code 605006 India

autor

Anandan P

• Takeida Pharmaceuticals Kathirkamam Puducherry Pin code 605009 India

autor

Saravanan D

• National College Department of Chemistry Trichirapalli Pin code 620001 Tamilnadu India

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