Determination of moxifloxacin hydrochloride in AVELOX pharmacological formulations using modified potentiometer sensors

Kumar, Sachin; Sindhu, Sushil K.; Kumar, Praveen; Sharma, Amit; Sagadevan, Suresh

doi:10.14314/polimery.2021.11.4

Artykuł - szczegóły

Tytuł artykułu

Determination of moxifloxacin hydrochloride in AVELOX pharmacological formulations using modified potentiometer sensors

Autorzy

Kumar Sachin , Sindhu Sushil K. , Kumar Praveen , Sharma Amit , Sagadevan Suresh

Treść / Zawartość

Pełne teksty:

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Identyfikatory

DOI

10.14314/polimery.2021.11.4

Warianty tytułu

Oznaczanie chlorowodorku moksyfloksacyny w formulacjach farmakologicznych AVELOX przy użyciu zmodyfikowanych czujników potencjometrycznych

Języki publikacji

Abstrakty

Three different carbon paste (CP), silk-screen (SP) and poly (vinyl chloride) (PVC) modified electrodes were obtained to verify the reliability of AVELOX, the generic name of which is Moxifloxacin HCl (AV-MOXH). The sensing membranes were containing AVELOX ion associated complexes with sodium tetraphenylborate (NaTPB), phosphomolybdic acid (PMA), phosphotungstic acid (PTA), and ammonium reineckate (RN) as electroactive materials. All three electrodes gave fast, viable, and near-Nernstian linear responses over a relative wide concentration range that ranged from 1.010-6 to 1.010-2 mol/L AV-MOXH at 25°C with a monovalent cationic decrease. The sensors demonstrated a good discernment of AV-MOXH from numerous inorganic and organic compounds such as glucose, sucrose, Na+, Ca+, etc. Additionally, the isothermal coefficients along with selectivity coefficients were calculated. The modified Screen Printed Electrode sensor appeared to be highly sensitive for the determination of AV-MOXH. The electrode response was observed in pH range 2–6 for ISPE electrodes and IPVC electrodes and 3–7 for ICPE electrodes under various temperature conditions. The short response time, lifetime validity, recovery, and all the methods of validation such as limit of detection and limit of quantification were estimated. The potentiometric method turned out to be suitable for determining AV-MOXH in pharmacological formulations, and the findings obtained are comparable to the “HPLC official method” in terms of the agreement. As a result, the postulated potentiometric approach was verified in accordance with IUPAC guidelines.

Otrzymano trzy różne elektrody modyfikowane pastą węglową (CP), sitodrukiem (SP) i polichlorkiem winylu (PVC), w celu oceny skuteczności działania leku AVELOX (nazwa rodzajowa Moxifloxacin HCl, AV-MOXH). Membrany czujników zawierały kompleksy jonu AVELOX z tetrafenyloboranem sodu (NaTPB), kwasem fosfomolibdenowym (PMA), kwasem fosfowolframowym (PTA) i soli Reineckego (RN) jako materiałami elektroaktywnymi. Wszystkie trzy elektrody dały szybkie i bliskie zależności liniowe Nernsta w zakresie stężeń AV-MOXH od 1.0-10-6 do 1.0-10-2 mol/l (w 25°C). Elektrody wykazały dobrą selektywność w oznaczaniu AV-MOXH względem wielu jonów i związków organicznych i nieorganicznych, jak glukoza, sacharoza, Na+, Ca+ itp. Dodatkowo obliczono współczynniki izotermiczne oraz współczynniki selektywności. Zmodyfikowany czujnik z elektrodą sitodrukową okazał się być bardzo czuły do oznaczania AV-MOXH. Badania prowadzono w zakresie pH 2–6 w przypadku elektrod ISPE i IPVC oraz 3–7 w przypadku elektrod ICPE w różnych temperaturach. Oszacowano czas odpowiedzi elektrod, ich czas życia, możliwość regeneracji, odzysk oraz granicę wykrywalności i granicę oznaczalności. Metoda potencjometryczna okazała się być odpowiednia do oznaczania AV-MOXH w preparatach farmakologicznych, a uzyskane wyniki są porównywalne z „oficjalną metodą HPLC”.

Słowa kluczowe

AVELOX moxifloxacin HCL ion-selective electrodes sodium tetraphenylborate phosphomolybdic acid phosphotungstic acid poly(vinyl chloride) potentiometry

AVELOX moksyfloksacyna HCL elektrody jonoselektywne tetrafenyloboran sodu kwas fosfomolibdenowy kwas fosfowolframowy poli(chlorek winylu) potencjometria

Wydawca

Sieć Badawcza Łukasiewicz – Instytut Chemii Przemysłowej

Czasopismo

Polimery

Rocznik

2021

Tom

T. 66, nr 11-12

Strony

589--601

Opis fizyczny

Bibliogr. 55 poz., rys. kolor., tab., wykr.

Twórcy

autor

Kumar Sachin

singhsachin001990@gmail.com

Department of Chemistry, S.S.V.P.G. College (Affiliated to C.C.S. University Meerut, Meerut), Hapur-245101, India

https://orcid.org/000-0002-9131-582X

autor

Sindhu Sushil K.

Department of Chemistry, S.S.V.P.G. College (Affiliated to C.C.S. University Meerut, Meerut), Hapur-245101, India

https://orcid.org/0000-0001-7944-8593

autor

Kumar Praveen

Department of Chemistry, S.S.V.P.G. College (Affiliated to C.C.S. University Meerut, Meerut), Hapur-245101, India

https://orcid.org/0000-0002-7219-9958

autor

Sharma Amit

Department of Applied Sciences and Humanities, Raj Kumar Goel Institute of Technology 5KM Stone Delhi-Meerut Road, Ghaziabad-201003, India

https://orcid.org/0000-0002-2878-1908

autor

Sagadevan Suresh

drsureshnano@gmail.com

Nanotechnology & Catalysis Research Centre, University of Malaya, Kuala Lumpur 50603, Malaysia

https://orcid.org/0000-0003-0393-7344

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021)

Typ dokumentu

Bibliografia

Identyfikator YADDA

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