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In vivo study of human mandibular distraction osteogenesis. P. 2, Determination of callus mechanical properties

Treść / Zawartość
Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Distraction Osteogenesis (DO) is a surgical technique used to reconstruct bone defects. To improve the current treatment protocols, the knowledge of the mechanical properties of the bone regenerate is of major interest. The aim of this study, constituting the second part of our paper previously published in Acta of Bioengineering and Biomechanics, was to identify the elastic and viscous properties of bone callus. This is done in the case of a mandibular DO by analyzing the experimental measurements of the forces imposed on bone regenerate by a distraction device. The bone transport forces were evaluated thanks to strain gauges glued on the distraction device. A rheological model describing the callus constitutive behavior was developed and the material constants involved were identified. The time-dependent character of the bone regenerate mechanical behavior was confirmed. The viscous response of the mesenchymal tissue was described by two characteristic times. The first one describing the viscoelastic callus behavior was estimated to be 140 seconds and the second one representing the permanent bone callus lengthening was evaluated to be 5646 seconds. An average value of 0.35 MPa for the regenerate Young’s modulus was deduced. The elastic properties of mesenchymal tissue found are in agreement with the rare data available in the literature.
Rocznik
Strony
11--18
Opis fizyczny
Bibliogr. 24 poz., rys., tab., wykr.
Twórcy
autor
  • Laboratory of Mechanics, Biomechanics, Polymers and Structures, Ecole Nationale d’Ingénieurs de Metz, Metz Cedex, France
autor
  • Orthopédie Biomécanique Locomotion, Chatillon, France
autor
  • Laboratory of Mechanics, Biomechanics, Polymers and Structures, Ecole Nationale d’Ingénieurs de Metz, Metz Cedex, France
autor
  • AP-HP, Department of Maxillo-facial Surgery, Pitié-Salpétrière University Hospital, Faculty of Medicine, Paris, France
Bibliografia
  • [1] ILIZAROV G.A., The Tension-Stress Effect on the Genesis and Growth of Tissues. Part II. The Influence of the Rate and Frequency of Distraction, Clin. Orthop. Relat. Res., 1989b, 239, 263–285.
  • [2] RICHARDS M., WINEMAN A.S., ALSBERG E., GOULET J.A., GOLDSTEIN S.A., Viscoelastic characterization of mesenchymal gap tissue and consequences for tension accumulation during distraction, ASME J. Biomech. Eng., 1999, 121, 116–123.
  • [3] BOCCACCIO A., PAPPALETTERE C., KELLY D.J., The Influence of Expansion Rates on Mandibular Distraction Osteogenesis: A Computational Analysis, Ann. Biomed. Eng., 2007, 35, 1940–1960.
  • [4] ILIZAROV G.A., The principles of the Ilizarov method, Bull. Hosp. Jt Dis. Orthop. Inst., 1988, 48, 1–11.
  • [5] ILIZAROV G.A., The Tension-Stress Effect on the Genesis and Growth of Tissues. Part I. The Influence of stability of fixation and soft-tissue preservation, Clin. Orthop. Relat. Res., 1989a, 238, 249–281.
  • [6] LI G., SIMPSON H.R.W., KENWRIGHT J., TRIFFITT J.T., Tissues formed during distraction osteogenesis in the rabbit are determined by the distraction rate: localization of the cells that express the MRNAS and the distribution of types I and II collagens, Cell. Biol. Int., 2000, 24, 24–33.
  • [7] al RUHAIMI K.A., Comparison of different distraction rates in the mandible: an experimental investigation, Int. J. Oral Maxillofac. Surg., 2001, 30, 220–227.
  • [8] KING N.S., LIU Z.J., WANG L.L., CHIU I.Y., WHELAN M.F., HUANG G.J., Effect of distraction rate and consolidation period on bone density following mandibular osteodistraction in rats, Arch. Oral Biol., 2003, 48, 299–308.
  • [9] REINA-ROMO E., GÓMEZ-BENITO M.J., GARCÍA-AZNAR J.M., DOMÍNGUEZ J., DOBLARÉ M., Modeling distraction osteogenesis: analysis of the distraction rate, Biomech. Model. Mechanobiol., 2009, 8, 323–335.
  • [10] IDELSOHN S., PLANELL J.A., GIL F.J., LACROIX D., Development of a dynamic mechano-regulation model based on shear strain and fluid flow to optimize distraction osteogenesis, J. Biomech., 2006, 39, S9–S10.
  • [11] LOBOA E.G., FANG T.D., PARKER D.W., WARREN S.M., FONG K.D., LONGAKER M.T., CARTER D.R., Mechanobiology of mandibular distraction osteogenesis: finite element analyses with a rat model, J. Orthop. Res., 2005, 23, 663–670.
  • [12] SAMCHUKOV M.L., COPE J.B., HARPER R.P., ROSS J.D., Biomechanical considerations of mandibular lengthening and widening by gradual distraction using a computer model, J. Oral Maxillofac. Surg., 1998, 56, 51–59.
  • [13] ARONSON J., HARP J.H., Mechanical forces as predictors of healing during tibial lengthening by distraction osteogenesis, Clin. Orthop. Relat. Res., 1994, 301, 73–79.
  • [14] BRUNNER U.H., CORDEY J., SCHWEIBERER L., PERREN S.M., Force required for bone segment transport in the treatment of large bone defects using medullary nail fixation, Clin. Orthop. Relat. Res., 1994, 301, 147–155.
  • [15] GARDNER T.N., EVANS M., SIMPSON A.H., KENWRIGHT J., A method of examining the magnitude and origin of soft and hard tissue forces resisting limb-lengthening, J. Biomed. Eng., 1997, 19, 405–411.
  • [16] GARDNER T.N., EVANS M., SIMPSON H., KENWRIGHT J.,Force-displacement behaviour of biological tissue during distraction osteogenesis, Med. Eng. Phys., 1998, 20, 708–715.
  • [17] WOLFSON N., HEARN T.C., THOMASON J.J., ARMSTRONG P.F., Force and stiffness changes during Ilizarov leg lengthening, Clin. Orthop. Relat. Res., 1990, 250, 58–60.
  • [18] YOUNGER A.S.E., MACKENSIE W.G., MORRISON J.B., Femoral forces during limb lengthening in children, Clin. Orthop. Relat. Res., 1994, 301, 55–63.
  • [19] LEONG P.L., MORGAN E.F., Measurement of fracture callus material properties via nanoindentation, Acta Biomater., 2008, 4, 1569–1575.
  • [20] LACROIX D., PRENDERGAST P.J., A mechano-regulation model for tissue differentiation during fracture healing: analysis of gap size and loading, J. Biomech., 2002, 35, 1163–1171.
  • [21] BONNET A.S., DUBOIS G., LIPINSKI P., SCHOUMAN T., submitted, In vivo study of human mandibular distraction osteogenesis. Part I: Bone transport force determination, Acta Bioeng. Biomech., 2012, 14, 3–14.
  • [22] LABBÉ D., NICOLAS J., KALUZINSKI E., SOUBEYRAND E., SABIN P., COMPÈRE J.F., BÉNATEAU H., Gunshot Wounds: Reconstruction of the lower face by osteogenic distraction, Plast. Reconstr. Surg., 2005, 116, 1596–1603.
  • [23] LAUTERBURG M.T., EXNER G.U., JACOB H.A., Forces involved in lower limb lengthening: an in vivo biomechanical study, J. Orthop. Res., 2006, 24, 1815–1822.
  • [24] REINA-ROMO E., GÓMEZ-BENITO M.J., GARCÍA-AZNAR J.M., DOMÍNGUEZ J., DOBLARÉ M., Growth mixture model of distraction osteogenesis: effect of pre-traction stresses, Biomech. Model Mechanobiol., 2010, 9, 103–115.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-e80ec563-bc51-47c7-9c74-c24d04b020d1
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