Syntezy oliwacyny

• Autorzy: Tylińska B. , Redzicka A.

Warianty tytułu

EN

Synthesis of olivacine

• Języki publikacji: PL

Abstrakty

EN

Olivacine (1,5-methyl-6H-pyrido[4,3-b]carbazole) is an isomer of ellipticine (5,11-dimethyl-6H-pyrido[4,3-b] carbazole). Both of these heterocyclic compounds are carbazole derivatives, which exhibit broad spectrum of biological activity [1], especially as antineoplastic agents [2–9]. These four-ring heterocycles can be isolated from natural sources [10–16], or prepared synthetically. Chemical literature described more than 20 method of synthesis of olivacine [2, 17–34]. In this paper we described five selected syntheses of this alkaloid. In the first one this compound can be obtained during a multistep synthesis starting from 1-benzenesulfonyl-2-lithioindole [35]. A shorter method to get olivacine was the condensation of indole with an ethylene ketal [35]. Third synthesis starts from obtaining benzenosulfonyloindol from indole [37]. Another way starts from the synthesis of 1-(tert-butoxy)carbonyloindol [38]. Fifth method to get olivacine is the synthesis from the 1H-indole -2-carboxylate [39].

Słowa kluczowe

PL

synteza; oliwacyna; pirydo[4,3-b]karbazol

EN

synthesis; olivacine; pyrido[4,3-b]carbazole

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2015
• Tom: [Z] 69, 11-12
• Strony: 983--995
• Opis fizyczny: Bibliogr. 41 poz., schem.

Twórcy

autor

Tylińska B.

• Katedra i Zakład Chemii Organicznej Uniwersytetu Medycznego we Wrocławiu ul. Borowska 211a, 50-556 Wrocław

autor

Redzicka A.

• Katedra i Zakład Chemii Leków Uniwersytetu Medycznego we Wrocławiu ul. Borowska 211, 50-556 Wrocław

Bibliografia

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