Development and validation of high-performance liquid chromatography method for the simultaneous monitoring of pantoprazole sodium sesquihydrate and domperidone maleate in plasma and its application to pharmacokinetic study

• Autorzy: Abbas Ghulam , Saadullah Malik , Rasul Akhtar , Shah Shahid , Khan Sajid Mehmood , Hanif Muhammad , Ahmed Muhammad Masood

Identyfikatory

DOI

10.1556/1326.2019.00525

• Języki publikacji: EN

Abstrakty

EN

A sensitive, inexpensive high-performance liquid chromatography–ultraviolet detection (HPLC–UV) method has been developed and validated for the simultaneous monitoring of pantoprazole sodium sesquihydrate (PSS) and domperidone maleate (DM) in rabbit plasma on a C18 column with UV detection at 285 nm. Box–Behnken design was used with 3 independent variables, namely, flow rate (X1), mobile phase composition (X2), and phosphate buffer pH (X3), which were used to design mathematical models. Response surface design was applied to optimize the dependent variables, i.e., retention time (Y1 and Y2) and percentage recoveries (Y3 and Y4) of PSS and DM. The method was sensitive and reproducible over 1.562 to 25 μg/mL. The effect of the quadratic outcome of flow rate, mobile phase composition, and buffer pH on retention time (p ˂ 0.001) and percentage recoveries of PSS and DM (p = 0.0016) were significant. The regression values obtained from analytical curve of PSS and DM were 0.999 and 0.9994, respectively. The percentage recoveries of PSS and DM were ranged from 94.5 to 100.41% and 94.77 to 100.31%, respectively. The developed method was applied for studying the pharmacokinetics of PSS and DM. The Cmax of test and reference formulations were 48.06 ± 0.347 μg/mL and 46.31 ± 0.398 μg/mL for PSS, and 15.11 ± 1.608 μg/mL and 12.06 ± 1.234 μg/mL for DM, respectively.

Słowa kluczowe

EN

pantoprazole; domperidone; HPLC

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2020
• Tom: Vol. 32, no. 3
• Strony: 157--165
• Opis fizyczny: Bibliogr. 29 poz., rys.

Twórcy

autor

Abbas Ghulam

• Bahauddin Zakariya University, Multan, Pakistan
• Government College University, Faisalabad, Pakistan

autor

Saadullah Malik

• Government College University, Faisalabad, Pakistan

autor

Rasul Akhtar

• Government College University, Faisalabad, Pakistan

autor

Shah Shahid

• Government College University, Faisalabad, Pakistan

autor

Khan Sajid Mehmood

• The Islamia University, Bahawalpur, Pakistan

autor

Hanif Muhammad

• Bahauddin Zakariya University, Multan, Pakistan

autor

Ahmed Muhammad Masood

• Bahauddin Zakariya University, Multan, Pakistan

Bibliografia

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Uwagi

PL

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).