Biomaterials with antibacterial activity

• Autorzy: Wysocka K. , Buzalewicz I. , Wieliczko A. , Kowal K. , Stręk W. , Podbielska H.
• Języki publikacji: EN

Abstrakty

EN

The sol-gel derived silica spheres with surfaces modified by silver nanoparticles were used to enhance the photodynamic effect. The silica nanoparticles were prepared by modified Stöber synthesis. The diameter of obtained silica spheres was ca. 100 nm. These silica spheres we used as a carrier for noble nanoparticles. It was shown that Ag-Au nanoparticles have an antibacterial activity against Escherichia coli. This effect depends on the nanoparticles concentration and it is stronger for higher concentrations. Laser irradiation enhances this effect, and starting from certain concentration it is possible to kill Escherichia coli, totally, when using laser light.

Słowa kluczowe

EN

biomaterials; silver nanoparticles; antibacterial activity

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2008
• Tom: Vol. 11, no. 81-84
• Strony: 119--121
• Opis fizyczny: Bibliogr. 11 poz., tab., wykr., zdj.

Twórcy

autor

Wysocka K.

• Wrocław University of Technology, Institute of Biomedical Engineering and Instrumentation, Bio-Optics Group, 27 Wybrzeże Wyspiańskiego, 50-370 Wrocław, Poland

autor

Buzalewicz I.

• Wrocław University of Technology, Institute of Biomedical Engineering and Instrumentation, Bio-Optics Group, 27 Wybrzeże Wyspiańskiego, 50-370 Wrocław, Poland

autor

Wieliczko A.

• Wrocław University of Environmental and Life Sciences, Faculty of Veterinary Medicine, Department of Epizootiology and Veterinary Administration with Clinic, 45 Grunwaldzki Sq.; 50-366 Wrocław, Poland

autor

Kowal K.

• Wrocław University of Technology, Institute of Biomedical Engineering and Instrumentation, Bio-Optics Group, 27 Wybrzeże Wyspiańskiego, 50-370 Wrocław, Poland

autor

Stręk W.

• Polish Academy of Sciences, Institute of Low Temperature and Structure Research, 2 Okólna str., 50-422 Wrocław, Poland

autor

Podbielska H.

• Wrocław University of Technology, Institute of Biomedical Engineering and Instrumentation, Bio-Optics Group, 27 Wybrzeże Wyspiańskiego, 50-370 Wrocław, Poland

Bibliografia

• [1] Kopelman R., Lee Koo Y.-E., Philbert M., Moffat B.A., Ramachandra Reddy G., McConville P., Hall D.E., Ross B.D. Multifunctional nanoparticle platforms for in vivo MRI enhancement and photodynamic therapy of a rat brain cancer, Journal of Magnetism and Magnetic Materials, 293 (1), 2005, pp. 404-410.
• [2] Tang, W., Xu, H., Park, E.J., Philbert, M.A., Kopelman, R, Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness , Biochemical and Biophysical Research Communications 369 (2),2008, pp. 579-583.
• [3] Oba, T., Photosensitizer nanoparticles for photodynamic therapy , Current Bioactive Compounds 3 (4), 2007, pp. 239-251
• [4] Taylor P W, Stapleton P D, Luzio P. New ways to treat bacterial infections. Drug Discov Today 2002;7:1086-1091.
• [5] Merchat M, Bertoloni G, Giacomini P, Villanueva A, Jori G. Meso-substituted catonic porphyrins as efficient photosensitisers of Gramm-positive and Gramm-negative bacteria. J Photochem Photobiol B:Biol 1996;32:153-157.
• [6] Minnock A, Vernon Di, Scholfield J, Griffiths J, Parish Jh, Brown Sb. Photoinactivation of bacteria. Use of cationic water-soluble zinc phtha- locyanines to photoinactivate both Gramm-negative and Grammpositive bacteria. J Photochem Photobiol B:Biol 1996;32:159-164.
• [7] Merchat M, Spikes G, Bertoloni G, Jori J. Studies on the mechanism of bacteria photosensitization by meso-substituted cationic porphyrins. J Photochem Photobiol B:Biol 1996;35:149-157.
• [8] Ulatowska-Jarża A., Zychowicz J, Hołowacz I., Bauer J., Razik J, Wieliczko A, Podbielska H., Muller G, Stręk W, Bindig U: Antimicrobial PDT with chlorophyll-derived photosensitizer and semiconductor laser, Med. Laser Appl. 2006 vol. 21 s. 177-183.
• [9] Stöber W., Fink A., Bohn E., Controlled growth of monodisperse silica spheres in the micron size range, Journal of Colloid and Interface Science 26, 1968, pp. 62-69.
• [10] Peterson M.S.M., Bouwman J., Chen A., Deutsch M., Inorganic metallodielectric materials fabricated using two single-step methods based on the Tollen's process, Journal of Colloid and Interface Science 306, 2007, s. 41-49.
• [11] Wysocka K., Bindig U., Bauer J., Stręk W., Kowal K., Podbielska H., Silver based nanomaterials - fluorescence enhancement in silver doped silica based nanobiomaterials, Conference on Biomaterials in Medicine and Veterinary Medicine, Rytro, 2008.

Uwagi

The work was supported by the Polish Ministry of Education and Scientific Research, Grant No. N N518 327335.