Antybiotyki fluorochinolonowe i ich modyfikacje strukturalne

• Autorzy: Komarnicka U. K. , Walencik P. K. , Lesiów M. K. , Krupa K.

Warianty tytułu

EN

Fluoroquinolone antibiotics and their structural modifications

• Języki publikacji: PL

Abstrakty

EN

The quinolones are synthetic antibiotics derived from nalidixic acid. Chemical modification of basic structure (nalidixic acid) has led to the development of a group of various compounds currently used in medicine. This article discusses the generation of quinolones, mode of their action, and relationship between activity and structure of these antibiotics. The most common quinolones, lomefloxacin and sparfloxacin were discussed in details, also the therapeutic potential of newer agents was reviewed. Recently, understanding of how molecular modifications among quinolone core structure can affect antimicrobial and anticancer activities has progressed rapidly. In this paper we discussed few examples of fluoroquinolone structural modifications. It was proved that many organic and inorganic compounds derived from fluoroquinolones overcame bacterial drug-resistance. Furthermore, chemical modification improved fluoroquinolone’s anticancer activities.

Słowa kluczowe

PL

antybiotyki fluorochnolonowe; modyfikacja strukturalna; sparfloksacyna; lomefloksacyna; właściwości przeciwbakteryjne; właściwości przeciwnowotworowe

EN

fluoroquinolone antibiotics; complexes; structural modifications; sparfloxacin; lomefloxacin; antibacterial properties; anticancer properties

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2018
• Tom: [Z] 72, 7-8
• Strony: 543--561
• Opis fizyczny: Bibliogr. 70 poz., schem.

Twórcy

autor

Komarnicka U. K.

• Wydział Chemii, Uniwersytet Wrocławski, ul. F. Joliot-Curie 14, 50-383 Wrocław

autor

Walencik P. K.

• Wydział Chemii, Uniwersytet Wrocławski, ul. F. Joliot-Curie 14, 50-383 Wrocław

autor

Lesiów M. K.

• Wydział Chemii, Uniwersytet Wrocławski, ul. F. Joliot-Curie 14, 50-383 Wrocław

autor

Krupa K.

• Wydział Chemii, Uniwersytet Wrocławski, ul. F. Joliot-Curie 14, 50-383 Wrocław

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).