Sole sodowe kwasów cholowych jako chiralne modyfikatory fazy ruchomej w układzie wysokosprawnej chromatografii cieczowej

• Autorzy: Kowalczyk M. , Asztemborska M.

Warianty tytułu

EN

Bile acid sodium salts as chiral modifiers of mobile phase in high performance liquid chromatography

• Języki publikacji: PL

Abstrakty

PL

W pracy opisano zastosowanie cholanu sodu i deoksycholanu sodu, jako modyfikatorów fazy ruchomej w wysokosprawnej chromatografii cieczowej. Własności enancjoseparacyjne micelarnych faz chiralnych dla optycznie czynnych pochodnych binaftyli: fosforanu- 1,1’- -binaftylo-2,2’-diylu oraz 1,1’-binaftylo-2,2’-diolu. Zbadano proces adsorpcji cholanu i deoksycholanu sodu na fazie C18. Zbadano wpływ stężenia i typu surfaktantu, jak również rodzaj i stężenie dodatku organicznego (n-alkohol) na proces rozpoznania chiralnego przez badane układy micelarne.

EN

In the paper the application of sodium cholate and sodium deoxycholate as modifiers of mobile phase in high performance liquid chromatography was described. Enantioseparation properties of micellar chiral phases were studied for optically active derivatives of binaphthyls: 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate and 1,1'-binaphthalene-2,2'-diol. The process of adsorption of sodium cholate and sodium deoxycholate on C18 phase was studied. The influence of type and concentration of surfactant as well as type and concentration of organic additive (n-alcohol) on process of chiral recognition was investigated. It has been found that enantiorecognition of bile salts micelle increase with the increase of the chain length of n-alcohol.

Słowa kluczowe

PL

pochodne binaftyli; rozdzielenie chiralne; cholan sodowy; deoksycholan sodowy; chiralne fazy ruchome; micelarna chromatografia cieczowa

EN

binaphthyl derivatives; chiral separation; sodium cholate; sodium deoxycholate; chiral mobile phases; micellar liquid chromatography

• Wydawca: Publishing House of Siedlce University of Natural Sciences and Humanities
• Czasopismo: Camera Separatoria
• Rocznik: 2011
• Tom: Vol. 3, No. 1
• Strony: 161--184
• Opis fizyczny: Bibliogr. 16 poz., tab., wykr.

Twórcy

autor

Kowalczyk M.

• Instytut Chemii Fizycznej Polskiej Akademii Nauk, 01-224 Warszawa, ul. Kasprzaka 44/52

autor

Asztemborska M.

• Instytut Chemii Fizycznej Polskiej Akademii Nauk, 01-224 Warszawa, ul. Kasprzaka 44/52

Bibliografia

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