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Recent data have demonstrated extensive autonomic nervous system (ANS) neural participation in malignant tumors and infiltration of nerve fibers in and around malignant tumors. ANS cybernetic imbalances deriving from central nervous system (CNS) stress are associated with poorer patient outcome and may play a key role in tumor expansion. The ANS modulates and can destabilize tissue stem cells, and it drives the expression of neurotransmitter receptors on tumor cells. Disruption of tumor innervation and pharmacological ANS blockade have abrogated cancer growth in preclinical models. The present review interprets recent key findings with respect to the ANS and cancer. We highlight new data from animal models addressing specific cancers suggesting that unbalanced autonomic cybernetic control loops are associated with tissue instability which in turn promotes, (1) cancer stem cell based tumor initiation and growth, and (2) metastasis. We posit that identifying the sources of neural control loop dysregulation in specific tumors may reveal potential targets for antitumor therapy. Given the striking tumor regression results obtained with gastric vagotomy in gastric cancer models, and the effects of b-adrenergic blockade in pancreatic tumor models, it may be feasible to improve cancer outcomes with therapeutics targeted to the nervous system.
Wydawca
Czasopismo
Rocznik
Tom
Strony
443--542
Opis fizyczny
Bibliogr. 100 poz., rys., wykr.
Twórcy
autor
- Department of Radiation Medicine and Applied Sciences, Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, United States
autor
- Translational Neurosciences, John Wayne Cancer Institute, Santa Monica, CA, United States
autor
- Department of Neurosciences, University of California San Diego, CA, United States
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Uwagi
PL
Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).
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Bibliografia
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