Determination of morphine, codeine, thebaine, papaverine and noscapine in rat plasma by UPLC-MS/MS

• Autorzy: Wang Ying , He Yifan , Wang Xianqin , Wen Congcong , Cao Jianbin

Identyfikatory

DOI

10.1556/1326.2023.01108

• Języki publikacji: EN

Abstrakty

EN

In this work, a UPLC-MS/MS assay was established for the determination of morphine, codeine, thebaine, papaverine and noscapine in rat plasma. ACQUITY UPLC BEH C18 column was employed for chromatographic separation with the mobile phase comprised acetonitrile-10 mmol L1 ammonium acetate aqueous solution (0.05% aqueous ammonia) using gradient elution. Midazolam was used as internal standard (IS). Electrospray ionization (ESI) in positive-ion mode with reaction monitoring (MRM) was used for quantitative analysis. The calibration curves for morphine, codeine, thebaine, papaverine and noscapine demonstrated good linearity (r > 0.995) in the range of 5–500 ng mL1 for morphine and codeine, and 1–100 ng mL1 for thebaine, papaverine and noscapine. The intra-day and inter-day precisions of morphine, codeine, thebaine, papaverine and noscapine were within 15%, the intra-day and inter-day accuracies were 89–114%, the recovery was better than 65%, and the matrix effects were 96–112%. The developed UPLC-MS/MS assay was successfully applied in the pharmacokinetics of papaverine and noscapine.

Słowa kluczowe

EN

morphine; codeine; thebaine; papaverine; noscapine; plasma; UPLC-MS/MS

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2024
• Tom: Vol. 36, no. 3
• Strony: 179--185
• Opis fizyczny: Bibliogr. 22 poz., rys., wykr.

Twórcy

autor

Wang Ying

• Pharmacy Department, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, China

autor

He Yifan

• Laboratory Animal Center, Wenzhou Medical University, Wenzhou, China

autor

Wang Xianqin

• Analytical and Testing Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Wen Congcong

• Laboratory Animal Center, Wenzhou Medical University, Wenzhou, China

• https://orcid.org/0000-0001-8413-1697

autor

Cao Jianbin

• Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China

• https://orcid.org/0000-0002-7631-3869

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