2-Etoksyetanol

• Autorzy: Sapota A. , Skrzypińska-Gawrysiak M

Warianty tytułu

EN

2-Etoxyethanol

• Języki publikacji: PL

Abstrakty

PL

2-Etoksyetanol (2-EE) jest bezbarwną cieczą o temperaturze wrzenia 135 oC stosowaną w wielu gałęziach przemysłu (chemicznego, metalurgicznego, mechanicznego, elektronicznego i meblowego) oraz w takich produktach powszechnego użytku, jak: atrament, kosmetyki, a także środki czyszczące. Na podstawie wyników badań toksyczności ostrej na zwierzętach wykazano, że według kryteriów klasyfikacji 2-etoksyetanol należy do związków szkodliwych. W warunkach narażenia zawodowego wchłania się do organizmu w drogach oddechowych oraz przez skórę (w postaci par i ciekłej). Na podstawie wyników zarówno badań na zwierzętach doświadczalnych (szczurach, myszach, królikach i psach), jak i badań epidemiologicznych ludzi narażonych zawodowo na działanie tego związku stwierdzono, że wykazuje on działanie hematotoksyczne oraz wpływa na rozrodczość. Skutki te u zwierząt doświadczalnych obserwowano jedynie po narażeniu na działanie związku o dużych stężeniach lub po podaniu zwierzętom dużych jego dawek. U zwierząt doświadczalnych 2-etoksyetanol wykazywał także działanie embriotoksyczne, fetotoksyczne i teratogenne. 2-Etoksyetanol nie wykazywał działania mutagennego ani rakotwórczego.

EN

2-Etoxyethanol (2-EE) is a colorless liquid with the boiling point of 135oC. It is used in numerous industries (chemical, metallurgic, mechanic, electronic and furniture), as well as in commonly used products, such as ink, cosmetics and detergents. The results of animal studies on acute toxicity have provided evidence that, according to the criteria of categorization, 2-etoxiethanol is a hazardous compound. In occupational exposure, 2-EE is absorbed by the body via the respiratory tract and the skin (in vapor and liquid forms). Both experimental studies on animals (rats, mice, rabbits and dogs) and epidemiological studies in human populations exposed to 2-EE have shown that this compound has a hematotoxic effect and affects reproduction. In laboratory animals these effects have been observed only after exposure to high concentrations or administration of high doses. It has also been observed that 2-EE hasembriotoxic, fetotoxic and teratogenic effects, however, neither there has been neither mutagenic nor carcinogenic effects. Epidemiological studies in persons occupationally exposed to this compound have demonstrated its hematotoxic effect and its impact on reproduction in men. The effects have been observed after exposure to ~10 mg/cm3, at the border of statistical significance; at the same time persons under study were additionally exposed to other chemical agents. The results of epidemiological studies have been a basis for estimating the maximum admissible concentration (MAC) of 2-EE, and the concentration of 10 mg/cm3is the value of no-observed adverse effect level (NOAEL). After using relevant coefficients of uncertainty the calculated MAC value of 2-EE is for 5 mg/cm3. This value should protect workers against potential hematological and spermatotoxic effects of this compound. There are no grounds for establishing its STEL value. In view of the extensive absorption of 2-EE by the skin, the compound should have the “Sk” symbol and because of its embriotoxic, fetotoxic and teratogenic effects, observed in animals, it is also suggested to use the “Ft” symbol as its additional denotation. The Interdepartmental Commission for Maximum Admissible Concentrations and Intensities for Agents Harmful to Health in the Working Environment at its 59th meeting has adopted for a 2-year period a MAC value of 2-EE proposed by SCOEL of 8 mg/m3. On the basis of the toxicokinetic model the value of the maximum admissible limit in biological material (BLV) is 60 mg of 2-ethoxyacetic acid/g creatinine in urine collected at the end of a working week.

Słowa kluczowe

PL

2-etoksyetanol; toksyczność; narażenie zawodowe; NDS

EN

2-ethoxyethanol; toxicity; occupational exposure; MAC

• Wydawca: Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy
• Czasopismo: Podstawy i Metody Oceny Środowiska Pracy
• Rocznik: 2011
• Tom: Nr 2 (68)
• Strony: 57--92
• Opis fizyczny: Bibliogr. 112 poz., tab.

Twórcy

autor

Sapota A.

• Uniwersytet Medyczny w Łodzi 90-151 Łódź ul. J. Muszyńskiego 1

autor

Skrzypińska-Gawrysiak M

• Uniwersytet Medyczny w Łodzi 90-151 Łódź ul. J. Muszyńskiego 1

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