Syntezy i aktywność biologiczna wybranych zasad Mannicha

• Autorzy: Nawrocka W. P. , Nowicka A.

Warianty tytułu

EN

Synthesis and biological activity of selected Mannich bases

• Języki publikacji: PL

Abstrakty

EN

The Mannich reaction is important for the synthesis and modification of biologically active compounds. Mannich bases – substituted products containing different heterocyclic system in their structures seem to be suitable candidates for further chemical modifications and might be of interest as pharmacologically active compounds. The main goal of this article is to present synthesis and biological activity of selected Mannich bases. Based on a review of the chemical literature, Mannich bases showed a multipharmacological effects. The Mannich bases, containing various heterocyclic systems were identified as potent anticancer agents. Presented compounds exhibit cytotoxic, antiproliferate in vitro, anticonvulsant, antioxidative, antiinflaminatory and analgesic activity. Some of them can be used in a treatment of diabetes and hypertension.

Słowa kluczowe

PL

zasada Mannicha; aktywność biologiczna; syntezy

EN

Mannich bases; biological activity; synthesis

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2014
• Tom: [Z] 68, 11-12
• Strony: 981--1008
• Opis fizyczny: Bibliogr. 37 poz., schem.

Twórcy

autor

Nawrocka W. P.

• Katedra i Zakład Technologii Leków Uniwersytet Medyczny im Piastów Śląskich we Wrocławiu ul. Borowska 211a, 50-556 Wrocław

autor

Nowicka A.

• Katedra i Zakład Technologii Leków Uniwersytet Medyczny im Piastów Śląskich we Wrocławiu ul. Borowska 211a, 50-556 Wrocław

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