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Ftalan benzylu butylu

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EN
Benzyl butyl phthalate
Języki publikacji
PL
Abstrakty
PL
Ftalan benzylu butylu (BBP) jest przezroczystą, oleistą cieczą o słabym zapachu stosowaną przede wszystkim jako dodatek zmiękczający do polimerów. Stosuje się ją powszechnie do produkcji płytek, pianek i wykładzin PCV. Ponadto jest wykorzystywana do produkcji uszczelniaczy (na bazie polisiarczków, poliuretanów, akrylanów), klejów i spoiw (na bazie poliakrylanów i polioctanu winylu), farb (na bazie poliuretanów i poliakrylanów) oraz atramentów i lakierów (na bazie akrylanów, nitrocelulozy i żywic winylowych). Podczas narażenia zawodowego na ftalan benzylu butylu znaczenie ma droga inhalacyjna, a w mniejszym stopniu kontakt związku ze skórą. Ze względu na niską prężność par w temperaturze pokojowej podwyższone stężenia ftalanu benzylu butylu mogą wystąpić jedynie w procesach technologicznych przebiegających w podwyższonej temperaturze lub w procesach związanych z występowaniem aerozoli ftalanu benzylu butylu w powietrzu środowiska pracy. Ftalan benzylu butylu jest związkiem o potwierdzonym szkodliwym działaniu na rozrodczość, natomiast w badaniach dotyczących jego toksyczności układowej najczęściej obserwowanymi skutkami narażenia u zwierząt był wzrost względnej i bezwzględnej masy wątroby i nerek. Skutek ten uznano za skutek krytyczny działania ftalanu benzylu butylu i zaproponowano przyjęcie stężenia 5 mg/m3 związku za jego wartość najwyższego dopuszczalnego stężenia (NDS). Zaproponowana wartość zabezpieczy pracowników również przed skutkami szkodliwego działania ftalanu benzylu butylu na rozrodczość. Z uwagi na to, że ftalan benzylu butylu nie wykazuje działania drażniącego, nie ma potrzeby ustalania wartości najwyższego dopuszczalnego stężenia chwilowego (NDSCh) dla tego związku. Zaleca się oznakowanie substancji w wykazie literą „Ft” – substancja działająca toksycznie na płód.
EN
Benzyl butyl phthalate (BBP) is a clear, oily liquid with a slight odour. It is used mostly as a plasticizer for polyvinyl chloride in vinyl floor tiles, vinyl foam and carpet backing. Furthermore, it is used in the production of sealants (polysulfide-, polyurethane-, or acrylic-based), adhesives (polyacrylic- and polyvinylacetate-based), paints (polyurethane- and polyacrylic-based), lacquers and inks (acrylic-, nitrocellulose- and vinyl resin-based). As far as occupational exposure is concerned, the inhalation route of exposure is important, and to a lesser extent dermal contact. Because of low vapour pressure at room temperature, the high concentration of BBP can only occur during technological processes where the temperature is elevated or BBP aerosols are generated. The reprotoxic activity of benzyl butyl phthalate has been confirmed, while in systemic toxicity studies increases in relative liver and kidney weights have been the most often observed effects. This effect was considered critical when the Polish OEL value of BBP was developed. It was agreed that the proposed value of 5 mg/m3 protected workers from the reproductive toxicity of BBP, too. It is also recommended to label BBP, in the Polish inventory of OELs, with the letters "Ft", a substance toxic to the foetus.
Słowa kluczowe
Rocznik
Tom
Strony
27--60
Opis fizyczny
Bibliogr. 63 poz., rys., tab.
Twórcy
  • Instytut Medycyny Pracy im. prof. dr. med. Jerzego Nofera 91-348 Łódź ul. św. Teresy od Dzieciątka Jezus 8
autor
  • Instytut Medycyny Pracy im. prof. dr. med. Jerzego Nofera 91-348 Łódź ul. św. Teresy od Dzieciątka Jezus 8
Bibliografia
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  • 2.Anderson W.A.R. i in. (2000) A biomarker approach to quantify human dietary exposure to phthalates, risk assessment and communication for food safety [Abstract]. Presented at the first joint CSL/JIFSAN symposium on food safety and nutrition 20-22 June 2000, Central Science Laboratory, Sand Hutton, York, UK. [cyt. za: RAR 2004].
  • 3.Ashby J. i in. (1997) Normal sexual development of rats exposed to butyl benzyl phthalates from conception to weaning. Regul. Toxicol. Pharmacol. 26, 102–118.
  • 4.Barber E.D. i in. (1987) Peroxisome induction on seven phthalate esters. Toxico. Indust. Health 2, 7–22.
  • 5.Bishop J.B., Teaf C.M., Bhooshan B. (1987) Assessment of fetal death rate among in utero progeny of B6C3F1 and CD-1 mice after subcutaneous injections of males with butyl bezyl phthalate (BBP). Environmental Mutagenicity Society (EMS) 9, suppl. 8, 15 [abstract].
  • 6.Calley D., Autian J., Guess W.L. (1966) Toxicology of a series of phthalate esters. J. Pharm. Sci. 55, 158– 162.
  • 7.CICAD, Concise International Chemical Assessment Document 17 (1999) Butyl benzyl phthalate. Geneva, World Health Organization.
  • 8.Duty S. i in. (2003) Phthalate exposure and human semen parameters. Epidemiology 14, 4 i 3, 269–277.
  • 9.Eigenberg D.A. i in. (1986) Distribution, excretion, and metabolism of butylbenzyl phthalate in the rat. J. Tox. Environ. Health 17, 445–456.
  • 10.Elsisi A.E., Carter D.E., Sipes I.G. (1989) Dermal absorption of diesters in rats. Fund. Appl. Toxico. 12, 70–77.
  • 11.Ema M. i in. (1990) Evaluation of the teratogenic potential of the plasticizer butyl benzyl phthalate in rats. J. Appl. Toxicol. 10, 339–343.
  • 12.Ema M., Itami T., Kawasaki H. (1991) Evaluation of the embryolethality of butyl benzyl phthalate by conventional and pair-feeding studies in rats. J. Appl. Toxicol. 11, 39–42.
  • 13.Ema M., Itami T., Kawasaki H. (1992a) Effect of period of exposure on the developmental toxicity of butyl benzyl phthalate in rats. J. Appl. Toxicol. 12, 57–61.
  • 14.Ema M., Itami T., Kawasaki H. (1992b) Embryolethality and teratogenicity of butyl benzyl phthalate in rats. J. Appl. Toxicol. 12, 179–183.
  • 15.Ema M., Itami T., Kawasaki H. (1992c) Teratogenic evaluation of butyl benzyl phthalate in rats by gastric intubation. Toxicology Letter 61, 1–7.
  • 16.Ema M., Itami T., Kawasaki K. (1993) Teratogenic phase specifity of butyl benzyl phthalate in rats. Toxicology 79, 11–19.
  • 17.Ema M. i in. (1994) Embryolethality of butyl benzyl phthalate during early pregnancy in rats. Reprod. Toxicol. 8, 231–236.
  • 18.Ema M., Miyawaki E., Kawashima K. (1998) Reproductive effects on butyl benzyl phthalate in pregnant and pseudopregnant rats. Reprod. Toxicol. 12, 127–132.
  • 19.Galloway S.M. i in. (1987) Chromosome abberations and sister chromatide exchanges in Chinese hamster ovary cells: evaluation of 108 chemicals. Environ. Mol. Mutagen. 10, 1–175.
  • 20.Gray Jr L.E. i in. (2000) Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol. Science 58, 350–365.
  • 21.Hammond B.G. i in. (1987) A review of the subchronic toxicity of butyl benzyl phthalate. Toxicol. Ind. Health 3, 79–98.
  • 22.Harper H.A., Rodwell V.W., Mayes P.A. (1977) Review of physiological chemistry. Los Altos, Lange Medical Publications.
  • 23.IARC (1999) Monographs on the evaluation of carcinogenic risks to humans. Vol 73. Some chemicals that cause tumours of the kidney or urinary bladder in rodents and some other substances. Lyon.
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  • 25.Lake B.G. i in. (1978) Studies on the metabolism and biological effects of n-butyl benzyl phthalate in the rat, BIBRA. Report 232/78, Project no. BB-76-312. Monsanto study BB-76-032.
  • 26.Latini G. i in. (2006) Phthalate exposure and male infertility. Toxicology 21, 226(2-3), 90–8.
  • 27.LeBoeuf R.A. i in. (1996) The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals. Mut. Res. 356, 85-127.
  • 28.Mallette F.S., von Haam E. (1952) Studies on the toxicity and skin effecys of compounds used in the rubber and plastics industries. Arch. Ind. Hyg. Occ. Med. 6, 231–236.
  • 29.Marsee K. i in. (2006) Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance. Environ Health Perspect. 114(6), 805–9.
  • 30.Mint A., Hotchkiss S.A.M. (1993) Percutaneous absorption of dimetyl phthalate and di-n-butyl phthalate through rat and human skin in vitro. Prediction of Percutaneous Penetration, vol. 3B.
  • 31.Milkov L.E. i in. (1973) Health status of workers exposed to phthalate plasticizers in the manufacture of artificial leather and films based on PVC resins. Environ. Health Perspect. 3, 175–178.
  • 32.Monsanto (1976a) Project no. Y-76-54. Acute oral toxicity rats. Acute dermal toxicity rabbits. Acute eye irritation rabbits. Primary skin irritation rabbits [cyt. za: RAR 2004].
  • 33.Monsanto (1976b) Project no. BO-76-017. Microbial plate assay [cyt. za: RAR 2004].
  • 34.Monsanto (1976c) Project no. LF-76-124C. Mutagenicity plate assai. Santicizer 160 [cyt. za: RAR 2004].
  • 35.Monsanto (1976d) Project no. BO-76-243-244. Mutagenicity testing of S-160 and benzyl chloride [cyt. za: RAR 2004].
  • 36.Monsanto (1980) Project no. SH-79-0006. Human repeat insult patch test with santicizer 160 (BBP) [cyt. za: RAR 2004].
  • 37.Monsanto (1981) Project no. ML-79-016/790047. Report no. MSL 1497. Sub-acute inhalation toxicity of santicizer 160 as an aerosol-vapour administrated for four weeks to Sprague-Dawley rats [cyt. za: RAR 2004].
  • 38.Monsanto (1982) Project no. 790179/ML-79-114. Report no. MSL-2713. Thirteen-week inhalation toxicity of santicizer 160 plasticizer vapour-aerosol to Sprague-Dawley rats [cyt. za: RAR 2004].
  • 39.Monsanto (1983) Project no. JH-81-302. Investigation of santicizer 160 (benzylbutyl phthalte) as a potential allergen [cyt. za: RAR 2004].
  • 40.Monsanto (1985) Project no. XX-85-069 (1985). Evaluation of santicizer 160 in the in vitro transformation of Balb/3T3 cell assai. Final Report. [cyt. za: RAR 2004].
  • 41.Monsanto (1992) Project no. AR-77-407. Evaluation of butyl benzyl phthalate in laying hens [cyt. za: RAR 2004].
  • 42.Monsanto (1993) Report xx-93-9101 (TNO Report v92.570). Dietary one-generation reproduction study with butyl benzyl phthalate in rats [cyt. za: RAR 2004].
  • 43.Monsanto (1997) Monsanto report no. CTL/R/1322. Butyl benzyl phthalate: comparative systemic exposure study following administration by oral and subcutaneous routes in immature female rats [cyt. za: RAR 2004].
  • 44.Nagao T. i in. (2000) Effect of butyl benzyl phthalate in Sprague-Dawley rats after gavage administration: a two-generation reproductive study. Reproductive Toxicology 14, 513–532.
  • 45.Nativelle C. i in. (1999) Metabolism of n-butyl benzyl phthalate in the female Wistar rat. Identification of new metabolites. Food Chem. Toxicol. 37, 905–917.
  • 46.Nielsen J., Aakesson B., Skerfing S. (1985). Phthalate ester exposure – Air levels and health of workers processing polyvinylchloride. Am. Ind. Hyg. Assoc. J. 46 (11), 643–647.
  • 47.NTP, National Toxicology Program (1982a) Technical Report serie No. 217. NIH publication no. 82-1773. Carcinogenesis bioassay of di(2-etylhexyl)phthalate in F344 rats and B6C3F1 mice (feed study).
  • 48.NTP, National Toxicology Program (1982b) NTP-80-25, NIH Publication no. 82-1769. Technical report serie no. 213. Carcinogenesis bioassay of butyl benzyl phthalate in F344/N rats and B6C3F1 mice (feed study).
  • 49.NTP, National Toxicology Program (1989) NTP Report No. 89-246. Final report developmental toxicity evaluation of butyl benzyl phthalate administered in feed to CD rats on gestational day 6 to 15.
  • 50.NTP, National Toxicology Program (1990) NTP report no. 90-114. Final report developmental toxicity of butyl benzyl phthalate in CD-1-Swiss mice.
  • 51.NTP, National Toxicology Program (1995) Report no. 460, NIH publication no. 95-3376. Effects of dietary restriction on toxicology and carcinogenesis studies in F344/N rats and B6C3F1 mice.
  • 52.NTP, National Toxicology Program (1997) Report no. 458, NIH publication no. 97-3374. Toxicology and carcinogenesis studies of butyl benzyl phthalate in F344/N rats (feed studies).
  • NTP-CERHR (2003) Monograph on the potential human reproductive and developmental effects of butyl benzyl phthalate (BBP). NIH Publication no. 03-4487.
  • 53.Piersma A.H., Verhoef A., Dortant P.M. (1995) Evaluation of the OECD 421 reproductive toxicity screening test protocol using butyl benzyl phthalate. Toxicology 99, 191–197.
  • 54.Piersma A.H. i in. (2000) Developmental toxicity of butyl benzyl phthalate in the rat using a multiple dose study design. Reprod. Toxicology 14, 417–425. From the report: Piersma A.H. i in. (1999) Developmental and testicular toxicity of butyl benzyl phthalate in the rat and the impact of study design. RIVM report no. 650040 001 [cyt. za: RAR 2004].
  • 55.Queiroz E.K., Waissmann W. (2006) Occupational exposure and effects on the male reproductive system. Cad Saude Publica 22(3), 485–93 [abstrakt].
  • 56.RAR, Risk Assessment Report (2004) Benzyl butyl phthalate, Draft March [ http://ecb.jrc.it/]
  • 57.Robinson E.C. (1991) Lack of neuropathological changes in rats after exposure to butyl benzyl phthalate. J. Toxicol. Environ. Health 32, 345–347.
  • 58.Singletary K., MacDonald C., Wallig M. (1997) The plasticizer benzyl butyl phthlate (BBP) inhibits 7,12- dimethylbenz[a]anthracene-induced rat mammary DNA adduct formation and tumorigenesis. Carcinogenesis 18, 1669–1673.
  • 59.Statsek N.K. (1974) Hygienic studies of some esters of phthalic acid and of polyvinylchloride materials plasticized by them. Gig. Sanit. 6, 25–28.
  • 60.Tyl R.W. i in. (2004) Reproductive toxicity evaluation of dietary butyl benzyl phthalate (BBP) in rats. Reproductive Toxicology 18, 241–264.
  • 61Uriu-Adams J.Y. i in. (2001) Effects of butyl benzyl phthalate on reproduction and zinc metabolism. Toxicology 159, 55–68.
  • 62.Valencia R. i in. (1985) Chemical mutagenesis testing in Drosophila. III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagenesis. 7, 325–348.
  • 63.Weuve J. i in. (2006) Exposure to phthalates in neonatal intensive care unit infants. Urinary concentrationsof monoesters and oxidative metabolites. Environmental Health Perspectives 114, 9, 1424.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-de268665-bcc9-464d-8358-2b207c26fa39
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