Structural role of exon-coded fragments in proteins

• Autorzy: Piwowar M. , Banach M. , Konieczny L. , Roterman I.
• Języki publikacji: EN

Abstrakty

EN

This article describes the role of protein fragments encoded by individual exons. Structural analysis of the hydrophobic core on the basis of the “fuzzy oil drop” model – in whole molecules as well as in fragments encoded by specific exons – indicates that, in each protein, at least one exon encodes a fragment, which is consistent with the theoretical distribution of hydrophobicity density. Quantitative assessment of the properties of such exons in selected proteins enables the model to be applied in identifying the structural (stabilizing) role of polypeptide chains encoded by individual exons. This is viewed as a preliminary step toward future exploitation of this technique in studying the alternative splicing phenomenon.

Słowa kluczowe

EN

divergence entropy; exon; fuzzy oil drop model; hydrophobic core

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2013
• Tom: Vol. 9, no. 3
• Strony: 103--114
• Opis fizyczny: Bibliogr. 41 poz., rys., tab., wykr.

Twórcy

autor

Piwowar M.

• Department of Bioinformatics and Telemedicine, Medical College, Jagiellonian University, Kraków, Poland

autor

Banach M.

• Department of Bioinformatics and Telemedicine, Medical College, Jagiellonian University, Kraków, Poland
• Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Kraków, Poland

autor

Konieczny L.

• Chair of Medical Biochemistry, Medical College, Jagiellonian University, Kraków, Poland

autor

Roterman I.

• Department of Bioinformatics and Telemedicine, Medical College, Jagiellonian University, Łazarza 16, 31-530 Kraków, Poland

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