The influence of selected transition elements on cell metabolism

• Autorzy: Terpiłowska Sylwia , Rafińska Katarzyna , Gołębiowski Adrian , Kowalkowski Tomasz , Buszewski Bogusław

Identyfikatory

DOI

10.2478/eces-2023-0043

• Języki publikacji: EN

Abstrakty

EN

The elements are present in the environment. Moreover, they are used in pharmacy and the production of new materials used in medical applications. They are often as environmental pollutants. They can accumulate in organisms and induce toxic effects on the cellular level. HepG2, L929 and Caco-2 cell lines were exposed to known concentrations of chromium chloride, iron chloride, nickel chloride, molybdenum trioxide and cobalt chloride (200 or 1000 μ M used alone and in combinations). Concentrations of chromium, iron, nickel, molybdenum and cobalt in the cell lysate and the culture medium were determined by ICP-MS. Moreover, sodium, potassium, calcium and magnesium concentrations were also measured. What is more, cells were observed under light and scanning electron microscope. The dose-dependent increase in the concentration of chromium, iron, nickel, molybdenum and cobalt in all cell lines after incubation with elements was observed. Potassium concentration decreases while sodium calcium and magnesium increase after incubation of cells with of mentioned elements. The incubation of cells with microelements induces cell morphology changes. The presented study shows the crucial role of tested microelements in the induction of cell death as a result of an imbalance of sodium, potassium, calcium and magnesium concentration inside the cell.

Słowa kluczowe

EN

chromium; iron; nickel; molybdenum; cobalt; cell metabolism; ICP-MS; SEM; biomaterials

PL

chrom; żelazo; nikiel; molibden; kobalt; metabolizm komórkowy; ICP-MS; SEM; biomateriały

• Wydawca: Towarzystwo Chemii i Inżynierii Ekologicznej
• Czasopismo: Ecological Chemistry and Engineering. S
• Rocznik: 2023
• Tom: Vol. 30, nr 4
• Strony: 471--488
• Opis fizyczny: Bibliogr. 30 poz., rys., tab.

Twórcy

autor

Terpiłowska Sylwia

• Jan Kochanowski University of Kielce, Collegium Medicum, Department of Surgical Medicine with the Laboratory of Medical Genetics, al. IX Wieków Kielc 19A, 25-317 Kielce, Poland, phone [phone], fax [phone]

• https://orcid.org/0000-0002-2988-9443

autor

Rafińska Katarzyna

• Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, ul. J. Gagarina 7, 87-100 Toruń, Poland

• https://orcid.org/0000-0002-3358-7317

autor

Gołębiowski Adrian

• Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, ul. J. Gagarina 7, 87-100 Toruń, Poland

• https://orcid.org/0000-0001-9321-286X

autor

Kowalkowski Tomasz

• Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, ul. J. Gagarina 7, 87-100 Toruń, Poland

• https://orcid.org/0000-0001-8866-0246

autor

Buszewski Bogusław

• Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, ul. J. Gagarina 7, 87-100 Toruń, Poland
• Professor Jan Czochralski Kuyavian-Pomeranian Scientific Technological Centre, ul. I. Krasińskiego 4, 87-100 Toruń, Poland

• https://orcid.org/0000-0002-5482-7500

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).