Ochratoxin A and Aflatoxin B1 as Factors of Bone Damage and Neurodegeneration Through the Influence on the Immunomodulation Processes of TNF-α and IL-6 Concentrations

Radzka-Pogoda, Agnieszka; Radzki, Radosław Piotr; Bieńko, Marek; Szponar, Jarosław; Sokołowska, Barbara; Kulik, Anna; Lewicka, Małgorzata; Borzęcki, Andrzej

doi:10.2478/phr-2022-0017

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Tytuł artykułu

Ochratoxin A and Aflatoxin B1 as Factors of Bone Damage and Neurodegeneration Through the Influence on the Immunomodulation Processes of TNF-α and IL-6 Concentrations

Autorzy

Radzka-Pogoda Agnieszka , Radzki Radosław Piotr , Bieńko Marek , Szponar Jarosław , Sokołowska Barbara , Kulik Anna , Lewicka Małgorzata , Borzęcki Andrzej

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Radzka-Pogoda_Ochratoksyna_PHR_3_2022.pdf

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DOI

10.2478/phr-2022-0017

Warianty tytułu

Ochratoksyna a i Aflatoksyna B1 jako czynniki uszkodzenia kości i neurodegeneracji poprzez wpływ stężeń TNF-α i IL-6 na procesy immunomodulacji

Języki publikacji

EN PL

Abstrakty

The wide distribution of mycotoxins, including aflatoxin B1 and ochratoxin A, in the environment and their influence on living organisms make them an interesting research problem. Numerous complications of intoxication with these substances are known, however, particular attention is paid to the effects on the skeletal and nervous systems. The inflammatory effect, presented by the increase in the concentration of cytokines - IL-6 and TNF-α may influence the immune dysregulation present in bone metabolism disorders, as well as in neurodegeneration. Mycotoxins also contribute to osteodegeneration by modifying vitamin D metabolism. Interestingly, and still unexplored, is the mechanism of intrauterine influence on bone metabolism and neurodegeneration processes. Understanding the above mechanisms may help in monitoring the toxic effects of intoxication with these toxins. It can also help develop methods of therapy for poisoning with this compound, in animals and humans.

Szerokie rozpowszechnienie mykotoksyn, w tym aflatoksyny B1 i ochratoksyny A, w środowisku oraz ich wpływ na organizmy żywe sprawiają, że stanowią one interesujący problem badawczy. Znane są liczne powikłania zatrucia tymi substancjami, jednak szczególną uwagę zwraca ich wpływ na układ kostny i nerwowy. Efekt zapalny, prezentowany przez wzrost stężenia cytokin - IL-6 i TNF-α może wpływać na dysregulację immunologiczną obecną w zaburzeniach metabolizmu kostnego, a także w neurodegeneracji. Mykotoksyny przyczyniają się również do osteodegeneracji poprzez modyfikację metabolizmu witaminy D. Interesujący i wciąż niezbadany jest mechanizm wpływu wewnątrzmacicznego na metabolizm kości i procesy neurodegeneracji. Zrozumienie powyższych mechanizmów może pomóc w monitorowaniu toksycznych skutków zatrucia tymi toksynami. Może również pomóc w opracowaniu metod terapii zatrucia tym związkiem u zwierząt i ludzi.

Słowa kluczowe

bone metabolism bone development bone remodelling mycotoxin aflatoxin B1 ochratoxin A neurodegeneration

metabolizm kości rozwój kości przebudowa kości mykotoksyna aflatoksyna B1 ochratoksyna A neurodegeneracja

Wydawca

Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej

Czasopismo

Polish Hyperbaric Research

Rocznik

2022

Tom

nr 3(80)

Strony

61--72

Opis fizyczny

Bibliogr. 73 poz., rys.

Twórcy

autor

Radzka-Pogoda Agnieszka

Department of Hygiene and Epidemiology, Medical University of Lublin, Poland
Doctoral School, Medical University of Lublin, Poland

autor

Radzki Radosław Piotr

radoslaw.radzki@up.lublin.pl

Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Poland

autor

Bieńko Marek

Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Poland

autor

Szponar Jarosław

Toxicology Clinic, Clinical Department of Toxicology and Cardiology, Stefan Wyszyński Regional Specialist Hospital, Medical University of Lublin, Poland

autor

Sokołowska Barbara

John Paul II University in Biała Podlaska, Poland

autor

Kulik Anna

Józef Pilsudski University of Physical Education in Warsaw, Faculty of Physical Education in Biała Podlaska, Poland

autor

Lewicka Małgorzata

Department of Epidemiology and Public Health, Medical University, Łódź, Poland

autor

Borzęcki Andrzej

Department of Hygiene and Epidemiology, Medical University of Lublin, Poland

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