Ochratoxin A and Aflatoxin B1 as Factors of Bone Damage and Neurodegeneration Through the Influence on the Immunomodulation Processes of TNF-α and IL-6 Concentrations

• Autorzy: Radzka-Pogoda Agnieszka , Radzki Radosław Piotr , Bieńko Marek , Szponar Jarosław , Sokołowska Barbara , Kulik Anna , Lewicka Małgorzata , Borzęcki Andrzej

Identyfikatory

DOI

10.2478/phr-2022-0017

• Języki publikacji: EN

Abstrakty

EN

The wide distribution of mycotoxins, including aflatoxin B1 and ochratoxin A, in the environment and their influence on living organisms make them an interesting research problem. Numerous complications of intoxication with these substances are known, however, particular attention is paid to the effects on the skeletal and nervous systems. The inflammatory effect, presented by the increase in the concentration of cytokines - IL-6 and TNF-α may influence the immune dysregulation present in bone metabolism disorders, as well as in neurodegeneration. Mycotoxins also contribute to osteodegeneration by modifying vitamin D metabolism. Interestingly, and still unexplored, is the mechanism of intrauterine influence on bone metabolism and neurodegeneration processes. Understanding the above mechanisms may help in monitoring the toxic effects of intoxication with these toxins. It can also help develop methods of therapy for poisoning with this compound, in animals and humans.

Słowa kluczowe

EN

bone metabolism; bone development; bone remodelling; mycotoxin; aflatoxin B1; ochratoxin A; neurodegeneration

• Wydawca: Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
• Czasopismo: Polish Hyperbaric Research
• Rocznik: 2022
• Tom: nr 3(80)
• Strony: 61--72
• Opis fizyczny: Bibliogr. 73 poz., rys.

Twórcy

autor

Radzka-Pogoda Agnieszka

• Department of Hygiene and Epidemiology, Medical University of Lublin, Poland
• Doctoral School, Medical University of Lublin, Poland

autor

Radzki Radosław Piotr

• Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Poland

autor

Bieńko Marek

• Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Poland

autor

Szponar Jarosław

• Toxicology Clinic, Clinical Department of Toxicology and Cardiology, Stefan Wyszyński Regional Specialist Hospital, Medical University of Lublin, Poland

autor

Sokołowska Barbara

• John Paul II University in Biała Podlaska, Poland

autor

Kulik Anna

• Józef Pilsudski University of Physical Education in Warsaw, Faculty of Physical Education in Biała Podlaska, Poland

autor

Lewicka Małgorzata

• Department of Epidemiology and Public Health, Medical University, Łódź, Poland

autor

Borzęcki Andrzej

• Department of Hygiene and Epidemiology, Medical University of Lublin, Poland

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