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The toxicity of benzene is not an issue of the past, especially in developing countries. Bone marrow toxicity is demonstrated among workers. In this study, the effect of simultaneous exposure to benzene and ethanol on benzene metabolism in mice was investigated by measuring the excretion of thioethers in urine. Urinary thioether excretion significantly decreased in the mice receiving both benzene and ethanol compared with the animals receiving benzene only. The assay of determining thioethers in urine samples in this study is a simple and low-cost method, thus suitable for routine use, especially in developing countries, not only for benzene,but also for other alkilating agents, which can be found during occupational exposure. Our results suggest that further research is needed to elucidate the mechanisms of decreased urinary excretion of thioether after simultaneous exposure to benzene and ethanol.
Słowa kluczowe
Wydawca
Rocznik
Tom
Strony
107--111
Opis fizyczny
Bibliogr. 29 poz., tab.
Twórcy
autor
- Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
autor
- Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
autor
- Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
autor
- Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
autor
- Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
autor
- Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Bibliografia
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- 3.Mikov MI, Mikov MM, Siriski J. Chronic exposure to toluene and xylene vapors and their effects on workers employed in the production of paints and varnishes. Arch Toxicol Kinet Xenobiot Metabol. 1994;2:15–24.
- 4.Infante P. The past suppression of industry knowledge of the toxicity of benzene to humans and potential bias in future benzene research. Int J Occup Environ Health. 2006;12(3):268–72.
- 5.Lan Q, Zhang L, Li G, Vermeulen R, Weinberg RS, Dosemeci M, et al. Hematotoxicity in workers exposed to low levels of benzene. Science. 2004;306:1774–6.
- 6.American Conference of Governmental Industrial Hygienists (ACGIH). Threshold limit values for chemical substances and physical agents and biological exposure indices for 2008. Cincinnati, OH, USA: ACGIH; 2008.
- 7.Bird MG, Greim H, Kaden KA, Rice JM, Snyder R. BENZENE 2009—health effects and mechanisms of bone marrow toxicity: implications for t-AML and the mode of action framework. Chem Biol Interact. 2010;184(1–2):3–6 (dx.doi.org/doi:10.1016/j.cbi.2009.12.001).
- 8.Nakajima T, Wang RS, Elovaara E, Park SS, Gelboin HV, Vainio H. A comparative study on the contribution of cytochrome P-450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liver. Biochem Pharmacol. 1992;43:251–7.
- 9.Bolt HM, Ross PH, Their R. The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine. Int Arch Occup Environ Health. 2003;76:174–85.
- 10.Khan HA. Benzene’s toxicity: a consolidated short review of human and animal studies. Hum Exper Toxicol. 2007;26:677–85.
- 11.Dehnen V. A study on urinary thioethers by detecting N-acetylcysteine and thiophenol after alkaline hydrolysis. Zentralbl Hyg Umweltmed. 1990;189:441–5.
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- 13.Sabourin PJ, Bechtold WE, Henderson RF. A high pressure liquid chromatographic method for the separation and quantification of watersoluble radiolabelled benzene metabolites. Anal Biochem. 1988;170:316–27.
- 14.Haufroid V, Lison D. Mercapturic acids revisited as biomarkers of exposure to reactive chemicals in occupational toxicology: a mini review. Int Arch Occup Environ Health. 2005;78:343–54.
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- 17.Kapetanovic IM, Mieyal JJ. Inhibition of acetaminophen-induced hepatotoxicity by phenacetin and its aloxy analogs. J Pharmacol Exp Ther. 1979;209:25–30.
- 18.De Rooij BM, Commandeur JN, Vermeulen JP. Mercapturic acids as biomarkers of exposure to electrophilic chemicals: applications to environmental and industrial chemicals. Biomarkers. 1998;3: 239–303.
- 19.Aldkofer F, Scherer G, Von Maltzan C, Von Meyerinck L, Jarczyk L, Martin F, et al. Dietary influences on urinary excretion of hydroxyphenanthrenes, thioethers and mutagenicity in man. IARC Sci Publ. 1990;104:415–20.
- 20.Aringer L, Lidums V. Influence of diet and other factors on urinary levels of thioethers. Int Arch Occup Environ Health. 1988;61:123–30.
- 21.Sinues B, Rueda P, Benitez J, Saenz MA, Bernal ML, Lanuza J, et al. Thioether excretion, urinary mutagenicity, and metabolic phenotype in smokers. J Toxicol Environ Health. 1994;43:327–38.
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- 23.Bird MG, Greim H, Snyder, R, Rice JM. International symposium: recent advances in benzene toxicity. Chem Biol Interact. 2005;153–154:1–5.
- 24.Fustinoni, S, Consonni, D, Campo, L, Burati M, Colombi A, Pesatori A, et al. Monitoring low benzene exposure: comparative evaluation of urinary biomarkers, influence of cigarette smoking, and genetic polymorphisms. Cancer Epidemiol Biomarkers Prev. 2005;14:2237–44.
- 25.Barbieri A, Violante FS, Sabatini L, Graziosi F, Mattioli S. Urinary biomarkers and low-level environmental benzene concentration: Assessing occupational and general exposure. Chemosphere. 2008;74:64–9.
- 26.Mikov I, Mikov A, Siriski J, Mikov M, Milovanov M. Effect of simultaneous exposure to benzene and ethanol on urinary phenol excretion in mice. J Occup Health. 2000;42:258–9.
- 27.Johansson I, Ingelman-Sundberg M. Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes. Cancer Res. 1988;48:5387–90.
- 28.Lieber CS. The discovery of the microsomal ethanol oxidiying system and its physiologic and pathologic role. Drug Metabol Rev. 2004;36(3-4):511–29.
- 29.Lieber CS. CYP2E1: from ASH to NASH. Hepatology Res. 2004;28:1–11.
Typ dokumentu
Bibliografia
Identyfikator YADDA
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