Positronium as a biomarker of hypoxia

Moskal, Paweł; Stępień, Ewa Ł.

doi:10.1515/bams-2021-0189

Artykuł - szczegóły

Tytuł artykułu

Positronium as a biomarker of hypoxia

Autorzy

Moskal Paweł , Stępień Ewa Ł.

Wybrane pełne teksty z tego czasopisma

Identyfikatory

DOI

10.1515/bams-2021-0189

Warianty tytułu

Języki publikacji

Abstrakty

In this review article, we present arguments demonstrating that the advent of high sensitivity total-body PET systems and the invention of the method of positronium imaging, open realistic perspectives for the application of positronium as a biomarker for in-vivo assessment of the degree of hypoxia. Hypoxia is a state or condition, in which the availability of oxygen is not sufficient to support physiological processes in tissue and organs. Positronium is a metastable atom formed from electron and positron which is copiously produced in the intramolecular spaces in the living organisms undergoing positron emission tomography (PET). Properties of positronium, such as e.g., lifetime, depend on the size of intramolecular spaces and the concentration in them of oxygen molecules. Therefore, information on the partial pressure of oxygen (pO2) in the tissue may be derived from the positronium lifetime measurement. The partial pressure of oxygen differs between healthy and cancer tissues in the range from 10 to 50 mmHg. Such differences of pO2 result in the change of ortho-positronium lifetime e.g., in water by about 2–7 ps. Thus, the application of positronium as a biomarker of hypoxia requires the determination of the mean positronium lifetime with the resolution in the order of 2 ps. We argue that such resolution is in principle achievable for organ-wise positronium imaging with the total-body PET systems.

Słowa kluczowe

biomarkers cancer hypoxia J-PET medical imaging multi-photon PET imaging neoplastic tissues positronium theranostics total-body PET

Wydawca

Uniwersytet Jagielloński - Collegium Medicum
Index Copernicus Sp. z o.o.

Czasopismo

Bio-Algorithms and Med-Systems

Rocznik

2021

Tom

Vol. 17, no. 4

Strony

311--319

Opis fizyczny

Bibliogr. 60 poz., rys.

Twórcy

autor

Moskal Paweł

p.moskal@uj.edu.pl

M. Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
Theranostics Center, Jagiellonian University, Kraków, Poland

https://orcid.org/0000-0002-4229-3548

autor

Stępień Ewa Ł.

e.stepien@uj.edu.pl

M. Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
Theranostics Center, Jagiellonian University, Kraków, Poland

https://orcid.org/0000-0003-3589-1715

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).

Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-dbf240a5-bcd9-48a8-9ac2-4f425268ed0a