Synthesis, characterization of biologically potent novel chalcones bearing urea, thiourea and acetamide linkages

• Autorzy: Mewada N. S. , Shah D. R. , Chikhalia K. H.
• Języki publikacji: EN

Abstrakty

EN

Three series of some novel chalcone based urea, thiourea and acetamide derivatives were designed, synthesized and screened for their antimicrobial and antifungal activities. All the synthesized compounds are first reported. The structures of the compounds were elucidated with the aid of elemental analysis and spectral methods including IR, 1H-NMR spectral data. The prepared compounds were evaluated for antibacterial activity against two Gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus), two Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also investigated for their antifungal activity using the broth micro dilution method. The bioassay results showed that compounds a few compounds showed good to superior in vitro antibacterial and antifungal activity.

Słowa kluczowe

EN

Chalcone; urea; thiourea; acetamide; antimicrobial activity and antifungal activity

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 17, iss. 3
• Strony: 281--294
• Opis fizyczny: Bibliogr. 25 poz., rys., tab.

Twórcy

autor

Mewada N. S.

• Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed-380009, Gujarat, India

autor

Shah D. R.

• Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed-380009, Gujarat, India

autor

Chikhalia K. H.

• Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed-380009, Gujarat, India

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