Detonation nanodiamond particles modified by non-steroidal anti-inflammatory drugs in vitro examination

• Autorzy: Mitura K. , Wilczek P. , Niemiec-Cyganek A. , Morenc M. , Dudek M. , Sobczyk-Guzenda A. , Fraczyk J. , Kolesińska B.
• Języki publikacji: EN

Abstrakty

EN

Most recently it has been found that nanodiamond particles have very interesting properties. There are number of research communications that detonation nanodiamond particles (NDPs) are fairly reactive and their surface can be effectively modified by chemical methods. The hydroxyl-modified NDPs were obtained by Fenton reaction, amine-functionalized NDPs were obtained by chemical reduction of the nitro- -functionalized surface and carboxyl-modified NDPs by oxidation by using H2O2 under acidic conditions. NDPs functionalized by hydroxyl- and amine- groups and amino groups were used for covalent binding of non-steroidal anti-inflammatory pharmaceuticals (aspirin, ketoprofen, ibuprofen, naproxen) via ester or amide bonds. These results of the studies proved the activity of the conjugates of active substance-NDP and study the rate of release of active substance from the NDPs surface by in vitro examinations with mouse fibroblasts. The progress of the reaction and the characteristics of the products were determined by using FT-IR. Chemical and physical structures of materials were also investigated by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS). DRIFT spectra show the modification of nanodiamond by ketoprofen, naproxen, ibuprofen and aspirin.

Słowa kluczowe

EN

detonation nanodiamond particles; chemical modification; anti-inflammatory drugs; FTIR spectroscopy; mouse fibroblasts

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2017
• Tom: Vol. 20, no. 140
• Strony: 12--20
• Opis fizyczny: Bibliogr. 31 poz., rys., tab., wykr., zdj.

Twórcy

autor

Mitura K.

• Koszalin University of Technology, Department of Biomedical Engineering, Śniadeckich 2,75-453 Koszalin, Poland

autor

Wilczek P.

• Fundation of Cardiac Surgery Development, Wolności 345a, 41-800 Zabrze, Poland

autor

Niemiec-Cyganek A.

• Fundation of Cardiac Surgery Development, Wolności 345a, 41-800 Zabrze, Poland

autor

Morenc M.

• Fundation of Cardiac Surgery Development, Wolności 345a, 41-800 Zabrze, Poland

autor

Dudek M.

• Lodz University of Technology, Institute of Materials Science and Engineering, Stefanowskiego 1/15, 90-924 Lodz, Poland

autor

Sobczyk-Guzenda A.

• Lodz University of Technology, Institute of Materials Science and Engineering, Stefanowskiego 1/15, 90-924 Lodz, Poland

autor

Fraczyk J.

• Lodz University of Technology, Faculty of Chemistry, Institute of Organic Chemistry, Żeromskiego 116, 90-924 Lodz, Poland

autor

Kolesińska B.

• Lodz University of Technology, Faculty of Chemistry, Institute of Organic Chemistry, Żeromskiego 116, 90-924 Lodz, Poland

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).