Genotype TNF-α(-308) and Silicosis on Factory Workers in Vietnam in 2020

• Autorzy: Nguyen Viet , Nguyen Thi Thu Huyen , Dao Xuan Dat , Vu Xuan Quy , Pham Thi Quan , Le Thi Kim Chung , Tran Huy Thinh , Le Thi Huong , Nguyen Ngoc Anh , Nguyen Viet Nhung , Nguyen Ngoc Hong , Luong Mai Anh , Le Thi Thanh Xuan

Identyfikatory

DOI

10.29227/IM-2021-02-43

• Języki publikacji: EN

Abstrakty

EN

The studFigy aims to determine the TNF-α single-nucleotide polymorphism TNF-α (-308) and assess the association of TNF-a(-308) SNP with the risk of silicosis among workers directly exposed to silica dust in Vietnam. A study was undertaken among 78 cases with silicosis and 103 controls without silicosis in Vietnam. Blood samples were collected for genomic DNA extraction from each subject. The phenotyping of TNF-α(-308) was performed using polymerase chain reaction‐based restriction fragment length polymorphism (PCR‐RFLP) and dye termination sequencing. Results: The average exposure time of the case group was slightly higher than that of the control group (12.46 ± 6.732 years vs. 12.09 ± 7.854 years). The majority of genotypes in both silicosis and non-silicosis was GG. When analyzing the concentration of TNF-α in the study participants' blood, it is shown that the average concentration of TNFα in the case group was higher than that in the control group. The genotype AG in the case group was 1.368 times higher than that in the control group. The percentage of all A alleles in the case group with silicosis was 1.342 times higher than the control group without the disease, similar to previous studies. Conclusion: The majority of genotypes in both groups was GG. The average concentration of TNF-α in blood, genotype AG, and the percentage of all A alleles in the case group was higher than that in the control group.

Słowa kluczowe

EN

silicosis; genotype; TNF-α; Vietnam

PL

TNF-α; Wietnam; genotyp

• Wydawca: Polskie Towarzystwo Przeróbki Kopalin
• Czasopismo: Inżynieria Mineralna
• Rocznik: 2021
• Tom: no. 2
• Strony: 459--466
• Opis fizyczny: Bibliogr. 22 poz., tab., wykr.

Twórcy

autor

Nguyen Viet

• Vietnam National Cancer Institute, Vietnam National Cancer Hospital, Hanoi, Vietnam
• Hanoi University of Public Health, Hanoi, Vietnam

autor

Nguyen Thi Thu Huyen

• Health Environment Management Agency, Ministry of Health, Hanoi, Vietnam

autor

Dao Xuan Dat

• Hanoi Medical University, Hanoi, Vietnam

autor

Vu Xuan Quy

• Hanoi Medical University, Hanoi, Vietnam

autor

Pham Thi Quan

• Hanoi Medical University, Hanoi, Vietnam

autor

Le Thi Kim Chung

• Hanoi Medical University, Hanoi, Vietnam

autor

Tran Huy Thinh

• Hanoi Medical University, Hanoi, Vietnam

autor

Le Thi Huong

• Hanoi Medical University, Hanoi, Vietnam

autor

Nguyen Ngoc Anh

• Hanoi Medical University, Hanoi, Vietnam

autor

Nguyen Viet Nhung

• National Lung Hospital, Hanoi, Vietnam

autor

Nguyen Ngoc Hong

• National Lung Hospital, Hanoi, Vietnam

autor

Luong Mai Anh

• Health Environment Management Agency, Ministry of Health, Hanoi, Vietnam

autor

Le Thi Thanh Xuan

• Hanoi Medical University, Hanoi, Vietnam

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).