Biocompatibility of L-lactide-co-glycolide-co-trimethylene-carbonate shape memory terpolymer with human chondrocytes

• Autorzy: Kłosek R. , Komacki J. , Orchel A. , Jelonek K. , Dobrzyński P. , Kasperczyk J. , Dzierżewicz Z.
• Języki publikacji: EN

Abstrakty

EN

Biomedical application of biodegradable shape memory terpolymers obtained from L-lactide, glycolide, trimethylene carbonate (TMC) have been intensively investigated in recent years. All applicable biomedical materials must be biocompatible, which means that they cannot cause toxic, cytotoxic, allergic, or carcinogenic reactions. The first study evaluating the biocompatibility of the material is determination of its cytotoxicity. The purpose of this study was to assess the biocompatibility of poly(L-lactide-co-glycolide-co-trimethylene-carbonate) 75:13:12, synthesized using Zr(Acac)4 as an initiator of polymerization. The terpolymer was degraded for 30, 60 and 90 days at 37§C in water. The effect of degradation products on the growth of human articular chondrocytes was determined using the sulforhodamine B assay. The examined terpolymer was characterized by means of NMR spectroscopy, GPC and DSC. The results showed that the studied terpolymer was biocompatible with tested cells.

Słowa kluczowe

EN

shape-memory polymers (SMP); biodegradable polymers; cytotoxicity; degradation products; in vitro; biocompatibility of terpolymer

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2012
• Tom: Vol. 15, no. 113
• Strony: 23--25
• Opis fizyczny: Bibliogr. 14 poz., tab., wykr.

Twórcy

autor

Kłosek R.

• Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice

autor

Komacki J.

• Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice

autor

Orchel A.

• Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice

autor

Jelonek K.

• Centre of Polymer and Carbon Materials PAS, Zabrze

autor

Dobrzyński P.

• Centre of Polymer and Carbon Materials PAS, Zabrze

autor

Kasperczyk J.

• Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice
• Centre of Polymer and Carbon Materials PAS, Zabrze

autor

Dzierżewicz Z.

• Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice

Bibliografia

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• [9] Pamuła E., Błażewicz M., Czajkowska B., Dobrzyński P., Bero M., Kasperczyk J.: Elaboration and Characterization of Biodegradable Scaffolds from Poly (L-lactide-co-glycolide) Synthesized with Low-Toxic Zirconium Acetyloacetonate. Annals of transplantation 9 (2004) 64-67.
• [10] Bouissou C., Walle C.: Poly(lactic-co-glycolic acid) microspheres. In: Uchegbu I. F, Schatzlein A. G. Polymers in Drug Delivery. CRC Taylor&Francis (2006) 81-99.
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• [13] Dobrzyński P., Pastusiak M., Bero M.: Less toxic acetylacetonates as initiators of trimethylene carbonate and 2,2-Dimethyl- trimethylene carbonate ring opening polymerization. J Polym Sci, Part A: Polym Chem 43 (2005) 1913-1922.
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Uwagi

EN

This work was financially supported by project MEMSTENT (Grant No: UDA-POIG.01.03.01-00-123/08-04).