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Biomedical application of biodegradable shape memory terpolymers obtained from L-lactide, glycolide, trimethylene carbonate (TMC) have been intensively investigated in recent years. All applicable biomedical materials must be biocompatible, which means that they cannot cause toxic, cytotoxic, allergic, or carcinogenic reactions. The first study evaluating the biocompatibility of the material is determination of its cytotoxicity. The purpose of this study was to assess the biocompatibility of poly(L-lactide-co-glycolide-co-trimethylene-carbonate) 75:13:12, synthesized using Zr(Acac)4 as an initiator of polymerization. The terpolymer was degraded for 30, 60 and 90 days at 37§C in water. The effect of degradation products on the growth of human articular chondrocytes was determined using the sulforhodamine B assay. The examined terpolymer was characterized by means of NMR spectroscopy, GPC and DSC. The results showed that the studied terpolymer was biocompatible with tested cells.
Czasopismo
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Tom
Strony
23--25
Opis fizyczny
Bibliogr. 14 poz., tab., wykr.
Twórcy
autor
- Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice
autor
- Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice
autor
- Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice
autor
- Centre of Polymer and Carbon Materials PAS, Zabrze
autor
- Centre of Polymer and Carbon Materials PAS, Zabrze
autor
- Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice
- Centre of Polymer and Carbon Materials PAS, Zabrze
autor
- Department of Biopharmacy, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice
Bibliografia
- [1] Behl M., Lendlein A.: Shape-memory polymers. Mater. Today 10 (2000) 20-28.
- [2] Jaros A., Smola A., Kasperczyk J.: Biodegradowalne polimery z pamięcią kształtu do zastosowań medycznych. Chemik 64,2 (2010) 87-96.
- [3] Smola A. et al.: New semi-crystalline bioresorbable materials with shape-memory properties. Engineering of Biomaterials 89-91 (2009) 82-87.
- [4] Gębarowska K. et al.: Bioresorbable lactide/glycolide/trimethylene carbonate terpolymers with shape recovery properties. Engineering of Biomaterials 63-64 (2007) 48-50.
- [5] Ratna D., Karger-Kocsis J.: Recent advances in shape memory polymers and composites: a review. J Mater Sci 43 (2008) 264-265.
- [6] Błażewicz S., Stoch L.: Biomateriały polimerowe. [W:] Nałęcz M.: Biocybernetyka i inżynieria biomedyczna 2000, Warszawa: Akademicka Oficyna Wydawnicza Exit (2003).
- [7] Bostman O., Vijanen J., Salminen S., Pihlajamaki H.: Response of articular cartilage and subchondral bone to internal fixation devices mad of poly-L-lactide: a histomorphometric and microradio¬graphic study on rabbits. Biomaterials 21 (2009) 2553-2560.
- [8] Cordwener F. W., Maarten F., Joziasse C. A. P., Schmitz J. P., Bos R. R. M., Rozema F. R., Pennings A. J.: Cytotoxicity of poly(96L/4D-lactide): the influence of degradation and sterilization. Biomaterials 21 (2000) 2433-2442.
- [9] Pamuła E., Błażewicz M., Czajkowska B., Dobrzyński P., Bero M., Kasperczyk J.: Elaboration and Characterization of Biodegradable Scaffolds from Poly (L-lactide-co-glycolide) Synthesized with Low-Toxic Zirconium Acetyloacetonate. Annals of transplantation 9 (2004) 64-67.
- [10] Bouissou C., Walle C.: Poly(lactic-co-glycolic acid) microspheres. In: Uchegbu I. F, Schatzlein A. G. Polymers in Drug Delivery. CRC Taylor&Francis (2006) 81-99.
- [11] Yu H., Wooley P. H., Yang S. Y.: Biocompatibility of Poly-ε-caprolactone-hydroxyapatite composite on mouse bone marrow-derived osteoblasts and endothelial cells. J Orthop Surg Res 4 (2009) 5.
- [12] Zhang Z., Grijpma D. W., Feijen J.: Creep-resistant Poros structures based on stereo-complex forming triblock copolymers of 1,3-trimethylene carbonate and lactides. J Mater Sci-Mater M 15 (2004) 381-385.
- [13] Dobrzyński P., Pastusiak M., Bero M.: Less toxic acetylacetonates as initiators of trimethylene carbonate and 2,2-Dimethyl- trimethylene carbonate ring opening polymerization. J Polym Sci, Part A: Polym Chem 43 (2005) 1913-1922.
- [14] Chłopek J., Morawska-Chochół A., Wietecha A.: The influence of processing on polylactide properties. Engineering of Biomaterials 89-91 (2009) 217-220.
Uwagi
EN
This work was financially supported by project MEMSTENT (Grant No: UDA-POIG.01.03.01-00-123/08-04).
Typ dokumentu
Bibliografia
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