Haemocompatibility and cytotoxic studies of non-metallic composite materials modified with magnetic nano and microparticles

• Autorzy: Szymonowicz M. , Rybak Z. , Fraczek-Szczypta A. , Paluch D. , Rusak A. , Nowicka K. , Blazewicz M.

Identyfikatory

DOI

10.5277/ABB-00076-2014-02

• Języki publikacji: EN

Abstrakty

EN

Purpose: Preventing the formation of blood clots on the surface of biomaterials and investigation of the reasons of their formation are the leading topics of the research and development of biomaterials for implants placed into the bloodstream. Biocompatibility and stability of a material in body fluids and direct effect on blood cell counts components are related both to the structure and physico-chemical state of an implant surface. The aim of this study was to determine haemocompatibility and cytotoxicity of polysulfone-based samples containing nano and micro particles of magnetite (Fe3O4). Methods: The polysulfone-based samples modified with nanometric and micrometric magnetite particles were examined. Physicochemical properties of the composites were determined by testing their wettability and surface roughness. The action of haemolytic, activation of coagulation system and cytotoxicity of composites was evaluated. Results: Wettability and roughness of materials were correlated with nanoparticles and microparticles content. In the tests of plasma coagulation system shortening of activated partial thromboplastin time for polysulfone with nano magnetite and with micro magnetite particles was observed in comparison with pure polysulfone. Prothrombine time and thrombine time values as well as fibrinogen concentration were unchanged. Haemolysis values were normal. Morphology and viability of cells were normal. Conclusions: Composites made from polysulfone modified with nanoparticles and microparticles of magnetite cause neither haemolytic nor cytotoxic reaction. These composites evoke plasma endogenous system activation.

Słowa kluczowe

EN

nanocomposite; magnetic particles; polysulfone; haemolysis; cell viability; coagulation systems

PL

nanokompozyty; cząstki magnetyczne; hemoliza; żywotność komórkowa; koagulacja

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2015
• Tom: Vol. 17, no. 3
• Strony: 49--58
• Opis fizyczny: Bibliogr. 25 poz., rys., tab.

Twórcy

autor

Szymonowicz M.

• Department of Experimental Surgery and Biomaterials Research, Medical University, Wrocław, Poland

autor

Rybak Z.

• Department of Experimental Surgery and Biomaterials Research, Medical University, Wrocław, Poland

autor

Fraczek-Szczypta A.

• Department of Biomaterials, AGH University of Science and Technology, Kraków, Poland

autor

Paluch D.

• Department of Experimental Surgery and Biomaterials Research, Medical University, Wrocław, Poland

autor

Rusak A.

• Department of Experimental Surgery and Biomaterials Research, Medical University, Wrocław, Poland

autor

Nowicka K.

• Department of Biomaterials, AGH University of Science and Technology, Kraków, Poland

autor

Blazewicz M.

• Department of Biomaterials, AGH University of Science and Technology, Kraków, Poland

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