Primary stenosis progression versus secondary stenosis formation in the left coronary bifurcation: A mechanical point of view

• Autorzy: Jahromi Reza , Pakravan Hossein Ali , Saidi Mohammad Said , Firoozabadi Bahar

Identyfikatory

DOI

10.1016/j.bbe.2018.11.006

• Języki publikacji: EN

Abstrakty

EN

Biomechanical forces and hemodynamic factors influence the blood flow and the endothelial cells (ECs) morphology. These factors behave differently beyond the coronary artery stenosis. In the present study, unsteady blood flow in the left coronary artery (LCA) and its atherosclerotic bifurcating vessels, left anterior descending (LAD) and left circumflex (LCX) arteries, were numerically simulated to investigate the risk of plaque length development and secondary plaque formation in the post-stenotic areas. Using fluid–structure interaction (FSI) model, compliance of arterial wall and vessel curvature variations due to cardiac motion were considered. The arteries included plaques at the beginning of the bifurcation. Stenosis degree varied from 40% to 70% based on diameter reduction. Healthy coronary artery was also reconstructed to compare with the atherosclerotic arteries. Circumferential and longitudinal strains of ECs as well as wall shear stress (WSS) were computed in different locations downstream of the stenosis. It was concluded that the most critical regions experiencing low circumferential strain and low WSS were located proximal to the plaque throat, and the effects of these parameters intensified by stenosis degree. The results proposed that primary plaque length progression is more probable than secondary plaque formation distal to the stenosis when the stenosis degree increases.

Słowa kluczowe

EN

stenosis; coronary arteries; wall shear stress; fluid structure interaction

PL

stenoza; tętnica wieńcowa; naprężenie styczne ścian

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2019
• Tom: Vol. 39, no. 1
• Strony: 188--198
• Opis fizyczny: Bibliogr. 46 poz., rys., wykr.

Twórcy

autor

Jahromi Reza

• Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran

autor

Pakravan Hossein Ali

• School of Mechanical Engineering, Shiraz University, Shiraz, Iran

autor

Saidi Mohammad Said

• Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran

autor

Firoozabadi Bahar

• Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran

Bibliografia

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Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).